CAJ | 학술논문

为探索一种较稳定的大鼠大脑中动脉闭塞（MCAO）模型，通过神经功能缺损评分、TTC 染色、脑含水量检测和病理观察等方法，对线栓法和改良三氯化铁法致大鼠大脑中动脉闭塞（MCAO）模型进行比较观察。结果表明，改良三氯化铁法致大鼠大脑中动脉闭塞（MCAO）模型组的神经功能缺损评分、脑梗死面积、脑含水量均高于线栓法模型组，两组之间有显著性差异。说明改良三氯化铁法致大鼠大脑中动脉闭塞（MCAO）模型在梗死范围的稳定性、脑水肿程度、梗死体积等方面都明显优于线栓组，使该模型推广成为可能。
위탐색일충교은정적대서대뇌중동맥폐새（MCAO）모형，통과신경공능결손평분、TTC 염색、뇌함수량검측화병리관찰등방법，대선전법화개량삼록화철법치대서대뇌중동맥폐새（MCAO）모형진행비교관찰。결과표명，개량삼록화철법치대서대뇌중동맥폐새（MCAO）모형조적신경공능결손평분、뇌경사면적、뇌함수량균고우선전법모형조，량조지간유현저성차이。설명개량삼록화철법치대서대뇌중동맥폐새（MCAO）모형재경사범위적은정성、뇌수종정도、경사체적등방면도명현우우선전조，사해모형추엄성위가능。
To acquire a more stable kind of middle cerebral artery occlusion (MCAO)rat model,The MCAO models induced by suture and modified ferric trichloride were compared and analyzed.through the method of neurological impairment scores,TTC staining,cerebral water content test and pathological observation.Results indicated that neurological impairment score,cerebral infarct size,cerebral water content of MCAO model group induced by modified ferric trichloride,were higher than those of the model group induced by suture,and the difference was significant.It can be concluded that modified ferric trichloride method was easier to operate,with higher success rate,and more stable than suture method on cerebral edema,infarct volume and weight,so that the model can be promoted to use.