CAJ | 학술논문

放射性臂丛神经损伤（ RIBRI）是指患者在放射治疗过程中，臂丛神经受高剂量或是单次大剂量照射后引起的臂丛神经功能障碍。发病机制尚不十分明确，放射性纤维化发挥了重要作用。致病因素主要为放射因素、联合治疗、个体差异等，导致患者发病情况不一。 RIBRI潜伏期为数月或数年，初期主要表现为上肢主观感觉异常或神经性疼痛，随着病变进展，逐渐发展为整个上肢感觉减退、麻痹无力、甚至瘫痪，神经性疼痛发生较少。该病可以通过患者的放射治疗史、无症状间歇期、临床特点、查体、MRI、肌电图等检查明确诊断，需注意与肿瘤转移或放射诱导性肿瘤相鉴别。 RIBRI是一种不可逆性疾病，目前尚无根治方法，重在预防，药物、手术等治疗起到一定缓解作用。
방사성비총신경손상（ RIBRI）시지환자재방사치료과정중，비총신경수고제량혹시단차대제량조사후인기적비총신경공능장애。발병궤제상불십분명학，방사성섬유화발휘료중요작용。치병인소주요위방사인소、연합치료、개체차이등，도치환자발병정황불일。 RIBRI잠복기위수월혹수년，초기주요표현위상지주관감각이상혹신경성동통，수착병변진전，축점발전위정개상지감각감퇴、마비무력、심지탄탄，신경성동통발생교소。해병가이통과환자적방사치료사、무증상간헐기、림상특점、사체、MRI、기전도등검사명학진단，수주의여종류전이혹방사유도성종류상감별。 RIBRI시일충불가역성질병，목전상무근치방법，중재예방，약물、수술등치료기도일정완해작용。
Radiation-induced brachial plexus injury (RIBPI) is a functional disorder of the brachial plexus (BP), caused by higher total radiation dose or higher single dose to the BP during radiation therapy (RT).The etiol-ogy involved in the development of RIBPI includes RT , combined treatment modalities , and individual susceptibility . Its latent may vary largely , from a few months to several years .Initial symptom may be subjective paresthesia or neu-ropathic pain in the upper extremities .Subsequently , the patients may suffer from hypesthesia in the upper extremi-ties, weakness, or even paralysis.The diagnosis of RIBPI is based on history of RT, interval with no symptom, clini-cal manifestation , physical exam , magnetic resonance imaging ( MRI ) , and electromyogram .Differential diagnosis should exclude metastasis from malignant disease or radiation-induced second malignance .It is believed that the RIB-PI is a progressive process which may eventually result in devastating functional consequences , and no effective mo-dality is available to treat this disease so far .Medication and surgery only play a palliative role in this disease .There-fore, methods for preventing BP injury before its onset appear particularly crucial .