中国血液流变学杂志
中國血液流變學雜誌
중국혈액류변학잡지
CHINESE JOURNAL OF HEMORHEOLOGY
2013年
2期
342-345
,共4页
氢化可的松%脂肪栓塞综合征%血液流变性
氫化可的鬆%脂肪栓塞綜閤徵%血液流變性
경화가적송%지방전새종합정%혈액류변성
hydrocortisone%fat embolism syndrome%hemorheological properties
目的探讨氢化可的松对脂肪栓塞综合征血液流变学特性的影响。方法采用油酸静脉注射法建立脂肪栓塞综合征动物模型，测定实验组（n=20）、对照组（n=20）和健康组（n=10）在24h、48h、72h的全血黏度（ηb）、血浆黏度（ηp）、红细胞压积（HCT）、校正全血黏度（ηb’）、红细胞聚集指数（EAI）、及血小板、纤维蛋白原和动脉血氧分压（PaO2）等指标。结果实验组死亡率为5%，显著低于对照组（35%）。实验组各时间点PaO2与对照组相比均明显升高（P＜0.05或P＜0.01），但仍低于健康组（P＜0.01）。实验组血小板和纤维蛋白原与健康组相比没有统计学差异，而对照组与实验组和健康组相比，血小板明显减少、纤维蛋白原水平明显增高（P＜0.01）。实验组与健康组之间ηb、ηb’无显著性差异（P＞0.05），而对照组与实验组、健康组比较，ηb无显著差异，但ηb’显著增高（P＜0.05或P＜0.01）。实验组各时间点ηp、HCT、EAI与健康组比较，除72h的HCT较低、EAI较高外，其余均无统计学差异（P＞0.05）。对照组与健康组和实验组相比，各时间点ηp、EAI均显著增高、HCT均显著下降（P＜0.05或P＜0.01）。结论脂肪栓塞综合征血液多呈高黏滞状态，氢化可的松可降低其血液黏滞度、改善组织供氧，从而改善脂肪栓塞综合征的预后。
目的探討氫化可的鬆對脂肪栓塞綜閤徵血液流變學特性的影響。方法採用油痠靜脈註射法建立脂肪栓塞綜閤徵動物模型，測定實驗組（n=20）、對照組（n=20）和健康組（n=10）在24h、48h、72h的全血黏度（ηb）、血漿黏度（ηp）、紅細胞壓積（HCT）、校正全血黏度（ηb’）、紅細胞聚集指數（EAI）、及血小闆、纖維蛋白原和動脈血氧分壓（PaO2）等指標。結果實驗組死亡率為5%，顯著低于對照組（35%）。實驗組各時間點PaO2與對照組相比均明顯升高（P＜0.05或P＜0.01），但仍低于健康組（P＜0.01）。實驗組血小闆和纖維蛋白原與健康組相比沒有統計學差異，而對照組與實驗組和健康組相比，血小闆明顯減少、纖維蛋白原水平明顯增高（P＜0.01）。實驗組與健康組之間ηb、ηb’無顯著性差異（P＞0.05），而對照組與實驗組、健康組比較，ηb無顯著差異，但ηb’顯著增高（P＜0.05或P＜0.01）。實驗組各時間點ηp、HCT、EAI與健康組比較，除72h的HCT較低、EAI較高外，其餘均無統計學差異（P＞0.05）。對照組與健康組和實驗組相比，各時間點ηp、EAI均顯著增高、HCT均顯著下降（P＜0.05或P＜0.01）。結論脂肪栓塞綜閤徵血液多呈高黏滯狀態，氫化可的鬆可降低其血液黏滯度、改善組織供氧，從而改善脂肪栓塞綜閤徵的預後。
목적탐토경화가적송대지방전새종합정혈액류변학특성적영향。방법채용유산정맥주사법건립지방전새종합정동물모형，측정실험조（n=20）、대조조（n=20）화건강조（n=10）재24h、48h、72h적전혈점도（ηb）、혈장점도（ηp）、홍세포압적（HCT）、교정전혈점도（ηb’）、홍세포취집지수（EAI）、급혈소판、섬유단백원화동맥혈양분압（PaO2）등지표。결과실험조사망솔위5%，현저저우대조조（35%）。실험조각시간점PaO2여대조조상비균명현승고（P＜0.05혹P＜0.01），단잉저우건강조（P＜0.01）。실험조혈소판화섬유단백원여건강조상비몰유통계학차이，이대조조여실험조화건강조상비，혈소판명현감소、섬유단백원수평명현증고（P＜0.01）。실험조여건강조지간ηb、ηb’무현저성차이（P＞0.05），이대조조여실험조、건강조비교，ηb무현저차이，단ηb’현저증고（P＜0.05혹P＜0.01）。실험조각시간점ηp、HCT、EAI여건강조비교，제72h적HCT교저、EAI교고외，기여균무통계학차이（P＞0.05）。대조조여건강조화실험조상비，각시간점ηp、EAI균현저증고、HCT균현저하강（P＜0.05혹P＜0.01）。결론지방전새종합정혈액다정고점체상태，경화가적송가강저기혈액점체도、개선조직공양，종이개선지방전새종합정적예후。
Objective To investigate the influence of hydrocortisone on the hemorheological properties in fat embolism syndrome.Methods Animal models of fat embolism syndrome were established by the oleic acid injection method.They were divided into experimental group(n=20),control group(n=20) and normal group(n=10) randomly.The whole blood viscosity(ηb),plasma viscosity(ηp),erythrocyte aggregation index(EAI),hematocrit value(HCT),platelet and fibrinogen levels at 24h,48h and 72h of the three groups were determined using the hemorheological detection techniques.Results Mortality rate in the experimental group was 5%,which was obviously lower than that in the control group(35%).PaO2 at different time points in the experimental group were higher than those in the control group(P<0.05 or P<0.01),but still lower than those in the normal group(P<0.01). There were no signiifcant difference between the experimental group and normal group in platelet and ifbrinogen levels.However,platelet levels were signiifcantly lower while ifbrinogen levels signiifcantly higher in the control group compared with the other two groups(P<0.01).There were no signiifcant difference inηb andηb’ between the experimental group and normal group.Butηb’ levels in the control group were signiifcantly higher than those in the experimental group amd normal group(P<0.05 or P<0.01).There were no signiifcant differences inηp, HCT, EAI between the experimental group and control group(P>0.05) except that HCT were lower and EAI were higher at 72h(P<0.05).ηp and EAI levels in the control group were signiifcantly higher and HTC were signiifcantly lower than those in the experimental and normal group(P<0.05 or P<0.01).Conclusions The blood is in a hyperviscous state in fat embolism syndrome.Hydrocortisone can reduce the blood viscosity,improve the oxygen supply of tissues,and then improve the prognosis of fat embolism syndrome.
