CAJ | 학술논문

目的：评价 omega-3预防过敏性疾病的有效性和安全性。方法计算机检索英文数据库（PubMed、EMBASE、SCI、Cochrane Library）及中文数据库（中国生物医学文献数据库、中文科技期刊全文数据库、中国期刊全文数据库、中华医学会数字化期刊），并辅手工检索，检索时间截止至2013年5月，收集omega-3预防过敏性疾病的随机对照试验。采用Cochrane系统评价手册文献质量评价标准评价纳入研究质量，用 RevMan 5．1软件进行 Meta分析。结果共纳入6个 RCT，各试验间基线均可比。Meta分析结果显示：Omega-3与安慰剂对比预防过敏性疾病（特应性皮炎，过敏性鼻炎，过敏性哮喘，食物性过敏）方面差异无统计学意义，各研究间不良反应报道较少，差异无统计学意义。结论虽然omega-3作为一种新型的免疫营养物质有其独特优势，但在 omega-3预防过敏性疾病方面无明显效果。
목적：평개 omega-3예방과민성질병적유효성화안전성。방법계산궤검색영문수거고（PubMed、EMBASE、SCI、Cochrane Library）급중문수거고（중국생물의학문헌수거고、중문과기기간전문수거고、중국기간전문수거고、중화의학회수자화기간），병보수공검색，검색시간절지지2013년5월，수집omega-3예방과민성질병적수궤대조시험。채용Cochrane계통평개수책문헌질량평개표준평개납입연구질량，용 RevMan 5．1연건진행 Meta분석。결과공납입6개 RCT，각시험간기선균가비。Meta분석결과현시：Omega-3여안위제대비예방과민성질병（특응성피염，과민성비염，과민성효천，식물성과민）방면차이무통계학의의，각연구간불량반응보도교소，차이무통계학의의。결론수연omega-3작위일충신형적면역영양물질유기독특우세，단재 omega-3예방과민성질병방면무명현효과。
Objective To assess the efficacy and the clinic value of omega-3 in prevention of allergic disease. Methods The database was retrieved from PubMed,EMBASE,SCI,the Cochrane Library,Chinese Biomedical Literature Database,China Journal Full Text Database and Chinese Medical Association Journals and references of the included studies up to May 2013.Randomized control trials(RCTs)of omega-3 versus placebo were included.The quality of the included studies was evaluated by handbook evaluation standard.The data were analyzed with RevMan 5 .1 from the Cochrane Collaboration.Results Six RCTs were included,and the baseline data of each trial were comparable.The meta-analysis showed that there were no statistical difference for omega-3 compared with placebo in prevention of allergic disease,such as atopic dermatitis,allergic rhinitis,allergic cough,food allergy.Conclusion This meta-analysis suggests that supplementation with omega-3 is probably unlikely to play an important role as a strategy in the prevention of sensitization or allergic disease.