CAJ | 학술논문

通过丙交酯与氨基碳酸脂共聚来改善聚乳酸的活性，再利用改性后的活性氨基与聚乙二醇接枝共聚来改善聚乳酸的亲水性，将两亲接枝共聚物作为药物载体材料，采用溶剂-反溶剂法制备载有疏水性抗癌药物多西紫杉醇的聚合物纳米粒子，纳米颗粒的尺寸约100 nm。
통과병교지여안기탄산지공취래개선취유산적활성，재이용개성후적활성안기여취을이순접지공취래개선취유산적친수성，장량친접지공취물작위약물재체재료，채용용제-반용제법제비재유소수성항암약물다서자삼순적취합물납미입자，납미과립적척촌약100 nm。
Nanoparticles based on poly(2-amino-1, 3-propanediol carbonic ester-co-lactide) -g- PEG(P(LA-co-CA)-mPEG) were prepared by using the emulsion solvent diffusion method. The copolymer of P (LA-co-CA) was prepared by using ring-opening polymerization with diethylzinc (ZnEt2) as initiator, and then benzyl oxygen group was taken off to obtain P (LA-co-CA). With the anticancer drug, docetaxel (DTX), as a model drug, the morphology of nanoparticles was characterized with scanning electron microscopy (SEM) and the size and size distribution were determined by dynamic light scattering (DLS). SEM images and DLS results revealed that the particles were spherical in shape and about 100 nm in size, which was suitable for intravenous injection and close to the typically required size under physiological conditions. Thus, nanoparticles of P (LA-co-CA)-mPEG could be used as biodegradable, biocompatible, and cell-specific targetable nano-structured carriers for intracellular delivery of hydrophobic anticancer drugs.