CAJ | 학술논문

目的：探讨血浆高同型半胱氨酸（HCY ）水平是否与血管性认知功能障碍有关。方法以合肥市第二人民医院神经内科162例明确诊断的腔隙性脑梗死患者为研究对象，将入组患者血浆的HCY水平划分为高HCY（82例）和正常HCY（对照组，80例）两组，并通过对这两组患者进行多维度的神经心理学成套量表测查，来评估其认知功能。组间比较采用t检验。结果与对照组相比，高HCY组患者在空间工作记忆（N-back）和执行功能（Stroop试验）方面成绩差异有统计学意义（t＝8.995～64.305，P均＜0.05），而在长时记忆中的自由回忆任务中（AVLT）的成绩差异无统计学意义（P均＞0.05）。结论血浆高HCY水平可能与脑梗死患者的认知功能障碍有关，主要表现为对其工作记忆以及执行功能的影响突出，而对其长时记忆障碍的影响并不显著。
목적：탐토혈장고동형반광안산（HCY ）수평시부여혈관성인지공능장애유관。방법이합비시제이인민의원신경내과162례명학진단적강극성뇌경사환자위연구대상，장입조환자혈장적HCY수평화분위고HCY（82례）화정상HCY（대조조，80례）량조，병통과대저량조환자진행다유도적신경심이학성투량표측사，래평고기인지공능。조간비교채용t검험。결과여대조조상비，고HCY조환자재공간공작기억（N-back）화집행공능（Stroop시험）방면성적차이유통계학의의（t＝8.995～64.305，P균＜0.05），이재장시기억중적자유회억임무중（AVLT）적성적차이무통계학의의（P균＞0.05）。결론혈장고HCY수평가능여뇌경사환자적인지공능장애유관，주요표현위대기공작기억이급집행공능적영향돌출，이대기장시기억장애적영향병불현저。
Objective To investigate the relationship between high level plasma homocysteine (HCY)and vascular cognitive impairment (VCI ).Methods One hundred and sixty-two patients with lacunar infarction were from the neurology department of the second hospital in Hefei,which were divided into two groups,one was high HCY group(82 cases),the other was of normal level group(80 cases).A battery of neurophysigical scales were used to evaluate their cognitive function.The differences between the two groups were compared by using t test.Results Compared with the normal controls,although the high HCY groups had been impaired in both working memory and Stroop test(t=8.995-64.305,all P<0.05),they had not been impaired in AVLT(all P>0.05 ).Conclusion It is possible that high level of plasma HCY may be related to vascular cognitive impairment,which have a main affection on working memory and Stroop test,but have rarely effection on long-term memory.