CAJ | 학술논문

丙烯酰胺是生产聚丙烯酰胺的原料，在化妆品中存在的微量丙烯酰胺是生产过程中添加聚丙烯酰胺引入的。由于丙烯酰胺具有神经毒性和潜在致癌性，已被列为化妆品中的限制使用成分，加强化妆品中丙烯酰胺的监测具有重要意义。本文综述了丙烯酰胺的来源、用途和危害性，总结了目前化妆品中丙烯酰胺测定的所用的样品前处理方法，以及丙烯酰胺气相色谱法、液相色谱法、液相色谱-串联质谱法等各种检测方法的最新研究进展，同时对化妆品样品中丙烯酰胺检测技术的发展趋势进行了展望，表明采用串联质谱技术（如GC-MS/MS、LC-MS/MS）对进行复杂样品中丙烯酰胺进行检测是未来的发展趋势。
병희선알시생산취병희선알적원료，재화장품중존재적미량병희선알시생산과정중첨가취병희선알인입적。유우병희선알구유신경독성화잠재치암성，이피렬위화장품중적한제사용성분，가강화장품중병희선알적감측구유중요의의。본문종술료병희선알적래원、용도화위해성，총결료목전화장품중병희선알측정적소용적양품전처리방법，이급병희선알기상색보법、액상색보법、액상색보-천련질보법등각충검측방법적최신연구진전，동시대화장품양품중병희선알검측기술적발전추세진행료전망，표명채용천련질보기술（여GC-MS/MS、LC-MS/MS）대진행복잡양품중병희선알진행검측시미래적발전추세。
Acrylamide is the raw material of production of polyacrylamide, trace amounts of acrylamide is introduced during cosmetic processing process. Acrylamide is a kind of prohibited substances in cosmetics due to the potential nerve toxicity and carcinogenicity, the quantity of acrylamide is also to be considered a marker of cosmetic quality. The properties, applications and toxicity of acrylamide in cosmetics are reviewed briefly. The sample pretreatment and determination methods of acrylamide in cosmetic, such as gas chromatography, gas chromatography-mass spectrometry and liquid chromatography-mass spectrometry are introduced. The tendency in the determination of acrylamide in cosmetic is predicted, Tandem mass spectrometry, such as GC-MS/MS and LC-MS/MS, will be the development of technology to determinate acrylamide in complicated cosmetic.