中国医药科学
中國醫藥科學
중국의약과학
CHINA MEDICINE AND PHARMACY
2014年
7期
48-51
,共4页
手足口病%柯萨奇病毒%肠道病毒A16型%肠道病毒EV71型
手足口病%柯薩奇病毒%腸道病毒A16型%腸道病毒EV71型
수족구병%가살기병독%장도병독A16형%장도병독EV71형
Hand-foot-and-mouth disease%Coxsackie virus%Intestinal virus type A16%Intestinal virus EV71 type
自从1948年Dalldorf在美国纽约州格林县的柯萨奇镇（Coxsackie New York）的患儿中发现并描述了一种后来被命名为柯萨奇病毒（Coxsackie virus）以来，直到1960 Alsop将由萨科奇病毒引起的疾病命名为手足口病（HFMD），随后在世界各地均发现存在手足口病的流行。我国于1980年首次报告手足口病，广西于1989年第一次发现并报告了该病，自2008年手足口病列为国家法定丙类传染病以来，广西对手足口病的病原体的基因型进行了详细的研究，结果显示其中肠道病毒71型（EV71）占41.70%，柯萨奇病毒A16型（CoxA16）阳性8.50%。同时证实广西分离的EV71与国内其他省流行的EV71流行株具有高度的同源性，同属于C4基因亚型C4b分支。资料显示手足口病在国内呈现自然流行消长趋势，尽管该病的疫苗研究取得了多方面的进展，但离现场应用仍然存在多方面的挑战。
自從1948年Dalldorf在美國紐約州格林縣的柯薩奇鎮（Coxsackie New York）的患兒中髮現併描述瞭一種後來被命名為柯薩奇病毒（Coxsackie virus）以來，直到1960 Alsop將由薩科奇病毒引起的疾病命名為手足口病（HFMD），隨後在世界各地均髮現存在手足口病的流行。我國于1980年首次報告手足口病，廣西于1989年第一次髮現併報告瞭該病，自2008年手足口病列為國傢法定丙類傳染病以來，廣西對手足口病的病原體的基因型進行瞭詳細的研究，結果顯示其中腸道病毒71型（EV71）佔41.70%，柯薩奇病毒A16型（CoxA16）暘性8.50%。同時證實廣西分離的EV71與國內其他省流行的EV71流行株具有高度的同源性，同屬于C4基因亞型C4b分支。資料顯示手足口病在國內呈現自然流行消長趨勢，儘管該病的疫苗研究取得瞭多方麵的進展，但離現場應用仍然存在多方麵的挑戰。
자종1948년Dalldorf재미국뉴약주격림현적가살기진（Coxsackie New York）적환인중발현병묘술료일충후래피명명위가살기병독（Coxsackie virus）이래，직도1960 Alsop장유살과기병독인기적질병명명위수족구병（HFMD），수후재세계각지균발현존재수족구병적류행。아국우1980년수차보고수족구병，엄서우1989년제일차발현병보고료해병，자2008년수족구병렬위국가법정병류전염병이래，엄서대수족구병적병원체적기인형진행료상세적연구，결과현시기중장도병독71형（EV71）점41.70%，가살기병독A16형（CoxA16）양성8.50%。동시증실엄서분리적EV71여국내기타성류행적EV71류행주구유고도적동원성，동속우C4기인아형C4b분지。자료현시수족구병재국내정현자연류행소장추세，진관해병적역묘연구취득료다방면적진전，단리현장응용잉연존재다방면적도전。
Dalldorf found and described what was named Coxsackie virus later in the children of Coxsackie New York of America in 1948. The disease caused by Coxsackie virus was named as hand-foot-and-mouth disease(HFMD) by Alsop in 1960. Later the disease was found prevalent in different areas worldwide. China first reported HFMD in 1980 and Guangxi first discovered and reported this disease in 1989. Since HFMD was classified as a national legal class C infectious disease in 2008, Guangxi had studied the pathogen genotypes of HFMD in detail and found that enterovirus 71(EV71) accounted for 41.70% and coxsackievirus A16(CoxA16) accounted for 8.50%. Meanwhile, the EV71 separated in Guangxi was highly homologous with the EV71 strains prevalent in other provinces and both belonged to the C4b branch of C4 gene subtype. Data show that HFMD presents a growth and decline trend of natural prevalence. Although the study of HFMD vaccines has achieved extensive progress, but their field application is still facing multiaspect challenges.
