CAJ | 학술논문

我国是食管癌高发国家，发病人数占全球一半以上，国内食管癌的死亡率为17.38/10万，居恶性肿瘤的第4位。miRNA是新发现的一种具有高度进化保守性的单链RNA，在转录后水平引起靶mRNA降解或翻译抑制。miRNA的表达水平与食管癌的类型、预后等密切相关。在外周血中，miRNA水平也表现出显著的肿瘤相关性、组织特异性和表达稳定性。随着食管癌发病率不断增加，人们更加关注食管癌的发病机制及早期分子生物学标志物的研究。
아국시식관암고발국가，발병인수점전구일반이상，국내식관암적사망솔위17.38/10만，거악성종류적제4위。miRNA시신발현적일충구유고도진화보수성적단련RNA，재전록후수평인기파mRNA강해혹번역억제。miRNA적표체수평여식관암적류형、예후등밀절상관。재외주혈중，miRNA수평야표현출현저적종류상관성、조직특이성화표체은정성。수착식관암발병솔불단증가，인문경가관주식관암적발병궤제급조기분자생물학표지물적연구。
China is a country of high incidence of esophageal cancer, incidence accounted for more than half of the world, the esophageal cancer mortality rate was 17.38/10 million, ranking the fourth malignant tumor. miRNA is a highly evolutionary conservation of the single stranded RNA newly found, cause the target mRNA degradation or translational inhibition at the post transcriptional level. Abnormal expression of miRNA and esophageal cancer occurrence, differentiation, metastasis and recurrence are closely related. In the peripheral blood, miRNA also showed significant tumor correlation, tumor tissue specificity and tumor expression stability. With the increasing incidence of esophageal cancer, the molecular mechanism of esophageal cancer and early molecular biomarkers will research more deeply. This paper reviewed the study on expression of miRNA occurred in diagnosis and treatment and prognosis of esophageal cancer.