北方药学
北方藥學
북방약학
JOURNAL OF NORTH PHARMACY
2014年
6期
75-75,76
,共2页
徐维%邓博%吴跃锐%梁盛枝%龚建安
徐維%鄧博%吳躍銳%樑盛枝%龔建安
서유%산박%오약예%량성지%공건안
非小细胞肺癌%经皮肺穿刺活检术%表皮生长因子受体基因突变
非小細胞肺癌%經皮肺穿刺活檢術%錶皮生長因子受體基因突變
비소세포폐암%경피폐천자활검술%표피생장인자수체기인돌변
non-small cell lung cancer%Percutaneous lung needle biopsy%epidemal growth factor receptor gene mutation
目的:探讨螺旋CT引导下经皮肺穿刺活检获得标本组织检测非小细胞肺癌(NSCLC)表皮生长因子受体(EGFR)基因突变的临床价值。方法:入组38例晚期或局部晚期无法手术的NSCLC患者,采用18G自动活检枪,经CT引导行皮肺穿刺活检获取肿瘤组织,行组织学诊断及EGFR基因检测,观察术后并发症,分析检测结果。结果:38例病例经穿刺活检均获得理想的病理标本进行组织学诊断和基因突变检测,其中腺癌患者突变率与非腺癌患者突变率差异有统计学意义;女性患者突变率与男性患者突变率差异亦有统计学意义;未发生严重并发症;EGFR基因突变患者使用吉非替尼治疗获得较好疗效。结论:CT引导的经皮肺穿刺活检技术安全有效,是晚期NSCLC获得肿瘤组织检测EGFR基因突变的可靠方法,可为临床药物分子靶向治疗提供依据。
目的:探討螺鏇CT引導下經皮肺穿刺活檢穫得標本組織檢測非小細胞肺癌(NSCLC)錶皮生長因子受體(EGFR)基因突變的臨床價值。方法:入組38例晚期或跼部晚期無法手術的NSCLC患者,採用18G自動活檢鎗,經CT引導行皮肺穿刺活檢穫取腫瘤組織,行組織學診斷及EGFR基因檢測,觀察術後併髮癥,分析檢測結果。結果:38例病例經穿刺活檢均穫得理想的病理標本進行組織學診斷和基因突變檢測,其中腺癌患者突變率與非腺癌患者突變率差異有統計學意義;女性患者突變率與男性患者突變率差異亦有統計學意義;未髮生嚴重併髮癥;EGFR基因突變患者使用吉非替尼治療穫得較好療效。結論:CT引導的經皮肺穿刺活檢技術安全有效,是晚期NSCLC穫得腫瘤組織檢測EGFR基因突變的可靠方法,可為臨床藥物分子靶嚮治療提供依據。
목적:탐토라선CT인도하경피폐천자활검획득표본조직검측비소세포폐암(NSCLC)표피생장인자수체(EGFR)기인돌변적림상개치。방법:입조38례만기혹국부만기무법수술적NSCLC환자,채용18G자동활검창,경CT인도행피폐천자활검획취종류조직,행조직학진단급EGFR기인검측,관찰술후병발증,분석검측결과。결과:38례병례경천자활검균획득이상적병리표본진행조직학진단화기인돌변검측,기중선암환자돌변솔여비선암환자돌변솔차이유통계학의의;녀성환자돌변솔여남성환자돌변솔차이역유통계학의의;미발생엄중병발증;EGFR기인돌변환자사용길비체니치료획득교호료효。결론:CT인도적경피폐천자활검기술안전유효,시만기NSCLC획득종류조직검측EGFR기인돌변적가고방법,가위림상약물분자파향치료제공의거。
Objective:To investigate the clinical valve of spiral CT-guided percutaneous lung biopsy for the detection of epidermal growth factor receptor (EGFR)gene mutations in patients with advanced non-small cell lung cancer (NSCLC)Methods :38 patients with inoperable advanced or locally-advanced NSCLC were enrolled in this study.By using an 18-gauge core biopsy instrument,CT-guided lung biopsy was performed in all patients to get tumor tissue for the histology diagnosis and the determination of EGFR gene mutations. Postoperative complications and histological results were analyzed. Results: Sufficient amount of tumor tissue used for the histological examination and the determination of EGFR gene mutations was successfully obtained by puncturing biopsy in all the 38 patients.The difference in the mutation rate between adenocarcinoma and non-adenocarcinoma was statistically significant.The difference in the mutation rate between female and male patients was also statistically significant.All the patients had excellent results and the patients with EGFR gene mutations tended to respond well to gefitinib.Conclusion:CT-guided 1ung biopsy is a effective and safe technique, which can be reliably used for the detection of EGFR gene mutations in patients with advanced NSCLC.Besides,this method can provide evidence for clinical targeting drug therapy.