CAJ | 학술논문

目的：研究黄芩苷（Baicalin）对金黄色葡萄球菌肺炎小鼠的保护作用。方法：建立体内金葡菌感染肺炎小鼠模型，检测通过黄芩苷治疗后模型小鼠死亡率、肺湿/干重比例、菌落定植数以及肺泡灌洗液内细胞因子的变化。结果：黄芩苷能够显著降低金葡菌肺炎小鼠的死亡率，小鼠肺脏金葡菌的定植数量及肺脏湿重/干重比；肺泡灌洗液分析试验结果表明，黄芩苷治疗显著减少肺泡灌洗液中主要炎症因子TNF-α、IL-1β和IL-6的含量。结论：黄芩苷可有效治疗小鼠金葡菌肺炎，同时为创新性抗感染药物的研发奠定坚实的基础。
목적：연구황금감（Baicalin）대금황색포도구균폐염소서적보호작용。방법：건입체내금포균감염폐염소서모형，검측통과황금감치료후모형소서사망솔、폐습/간중비례、균락정식수이급폐포관세액내세포인자적변화。결과：황금감능구현저강저금포균폐염소서적사망솔，소서폐장금포균적정식수량급폐장습중/간중비；폐포관세액분석시험결과표명，황금감치료현저감소폐포관세액중주요염증인자TNF-α、IL-1β화IL-6적함량。결론：황금감가유효치료소서금포균폐염，동시위창신성항감염약물적연발전정견실적기출。
Objective:This study aim to evaluate the effects of baicalin to Staphylococcus aureus(S. aureus) in mice. Methods:The mouse model of S. aurues pneumonia was established to assess the in vivo performance of baicalin, the mortality, lung wet-dry ratio, bacterial count and alteration of cytokine were studied. Results:The results showed that treated mice with baicalin significantly decreased the mortality and the colony forming units (CFUs) in the lung tissues. The lung wet-dry ratio was also reduced, indicating that the pulmonary edema was alleviated. Analysis of bronchoalveolar lavage (BAL)fluid revealed that treated mice with baicalin led to a marked reduction in IL-1β, TNF-α and IL-6 concentrations in BAL fluids. Conclusion:The findings in our study indicated that baicalin protects lung damage from S. aureus, and our study will lay the foundation for development of?innovative?anti-infective drugs.