中国中医药信息杂志
中國中醫藥信息雜誌
중국중의약신식잡지
CHINESE JOURNAL OF INFORMATION ON TRADITIONAL CHINESE MEDICINE
2013年
9期
31-33,36
,共4页
商学征%马卫国%白羽%房铁生%张春艳%刘惠%陆妍%顾文%徐玉梅%谭玲%孟凤仙
商學徵%馬衛國%白羽%房鐵生%張春豔%劉惠%陸妍%顧文%徐玉梅%譚玲%孟鳳仙
상학정%마위국%백우%방철생%장춘염%류혜%륙연%고문%서옥매%담령%맹봉선
复方青秦液%尿酸性肾病%肾功能%大鼠
複方青秦液%尿痠性腎病%腎功能%大鼠
복방청진액%뇨산성신병%신공능%대서
Compoud Qingqin Liquids%uric acid nephropathy%renal function%rats
目的观察复方青秦液对尿酸性肾病大鼠肾功能的影响,探讨其肾脏保护作用。方法将SD大鼠随机分为正常组、模型组、阳性药组及中药大、中、小剂量组,用腺嘌呤灌胃伴饲酵母造模。正常组及模型组每日灌胃蒸馏水,阳性药组每日灌胃别嘌呤9.33 mg/kg,中药大、中、小剂量组每日灌胃复方青秦液3.77、1.89、0.09 g/kg,连续6周。观察各组大鼠一般情况,电镜、光镜观察肾脏病理变化,分别检测治疗前后尿蛋白浓度、血尿酸、血尿素氮、血肌酐、肾重指数。结果造模前后各组大鼠进食、饮水及体质量无明显变化。复方青秦液可明显降低尿酸性肾病大鼠的尿蛋白浓度,降低血尿酸水平,降低血肌酐、尿素氮,减少肾重指数(P＜0.05),中药大剂量组大鼠肾小管上皮细胞萎缩及肾间质纤维化不明显。结论复方青秦液对尿酸性肾病大鼠肾功能损伤具有保护作用。
目的觀察複方青秦液對尿痠性腎病大鼠腎功能的影響,探討其腎髒保護作用。方法將SD大鼠隨機分為正常組、模型組、暘性藥組及中藥大、中、小劑量組,用腺嘌呤灌胃伴飼酵母造模。正常組及模型組每日灌胃蒸餾水,暘性藥組每日灌胃彆嘌呤9.33 mg/kg,中藥大、中、小劑量組每日灌胃複方青秦液3.77、1.89、0.09 g/kg,連續6週。觀察各組大鼠一般情況,電鏡、光鏡觀察腎髒病理變化,分彆檢測治療前後尿蛋白濃度、血尿痠、血尿素氮、血肌酐、腎重指數。結果造模前後各組大鼠進食、飲水及體質量無明顯變化。複方青秦液可明顯降低尿痠性腎病大鼠的尿蛋白濃度,降低血尿痠水平,降低血肌酐、尿素氮,減少腎重指數(P＜0.05),中藥大劑量組大鼠腎小管上皮細胞萎縮及腎間質纖維化不明顯。結論複方青秦液對尿痠性腎病大鼠腎功能損傷具有保護作用。
목적관찰복방청진액대뇨산성신병대서신공능적영향,탐토기신장보호작용。방법장SD대서수궤분위정상조、모형조、양성약조급중약대、중、소제량조,용선표령관위반사효모조모。정상조급모형조매일관위증류수,양성약조매일관위별표령9.33 mg/kg,중약대、중、소제량조매일관위복방청진액3.77、1.89、0.09 g/kg,련속6주。관찰각조대서일반정황,전경、광경관찰신장병리변화,분별검측치료전후뇨단백농도、혈뇨산、혈뇨소담、혈기항、신중지수。결과조모전후각조대서진식、음수급체질량무명현변화。복방청진액가명현강저뇨산성신병대서적뇨단백농도,강저혈뇨산수평,강저혈기항、뇨소담,감소신중지수(P＜0.05),중약대제량조대서신소관상피세포위축급신간질섬유화불명현。결론복방청진액대뇨산성신병대서신공능손상구유보호작용。
Objective To observe the effect of Compoud Qingqin Liquids on renal function of rat model of uric acid nephropathy, and to discuss its protection of renal function. Methods The rat model was induced by gavaging adenine and feeding yeast. SD rats were randomly divided into control group, model group, positive group, and high-, medium-, low-dose groups of Chinese medicine. Blank control group and model group were daily gavaged with distilled water, positive control group was daily gavaged with allopurinol by 9.33 mg/kg, and high-, medium-, low-dose group of Chinese medicine was daily gavaged with Compound Qinggin Liguids by 3.77, 1.89, 0.09 g/(kg·d) respectively for 6 weeks. General condition of rats were observed, renal pathological changes were observed with light and electron microscope. Urine protein concentration, blood uric acid, blood urea nitrogen, creatinine and kidney weight index were respectively tested before and after treatment. Results There were no significant differences in eating, drinking and body weight between before and after modeling. Compoud Qingqin Liquids can obviously decrease the concentration of urine protein, blood uric acid, serum creatinine, blood urea nitrogen, and kidney weight index (P<0.05) of rats with uric acid nephropathy. Renal tubular epithelial cells atrophy and renal interstitial fibrosis of high-dose group of Chinese medicine were not evident. Conclusion Compoud Qingqin Liquids can protect the rats renal function against uric acid renal injury.
