CAJ | 학술논문

目的：建立气相色谱法测定布洛芬注射液中的杂质F。方法采用气相色谱法，色谱柱：DB-WAXetr 毛细管柱（25 m ×0．53 mm ×2μm），载气为氦气，流速5．0 mL· min-1，检测器为火焰离子化检测器，检测器温度为250℃，进样温度为200℃。结果在选定的条件下布洛芬和杂质完全分离，杂质F的检测限为2．5 mg· L-1，检测方法的精密度、准确度、灵敏度均达到了预定的分析要求。结论建立的方法准确、灵敏，适用于检测布洛芬注射液中的杂质F。
목적：건립기상색보법측정포락분주사액중적잡질F。방법채용기상색보법，색보주：DB-WAXetr 모세관주（25 m ×0．53 mm ×2μm），재기위양기，류속5．0 mL· min-1，검측기위화염리자화검측기，검측기온도위250℃，진양온도위200℃。결과재선정적조건하포락분화잡질완전분리，잡질F적검측한위2．5 mg· L-1，검측방법적정밀도、준학도、령민도균체도료예정적분석요구。결론건립적방법준학、령민，괄용우검측포락분주사액중적잡질F。
Objective To establish a GC method to determine the impurity F in ibuprofen and its preparations .Methods The GC method was performed on a ZB-WAXetr capillary column (25 m ×0.53 mm ×2 μm) and FID detector.The carrier gas was He with flow rate at 5 ml/min.The injector temperature and the detector temperature were 200℃and 250℃,respectively.Results Under the described chromatographic condition ,The impurity F was completely separated from ibuprofen .The LOD of impurity F was 2.5 mg· L-1 .Conclusions The analytical method is simple ,accurate and sensitive with good reproducibility .It can be used to determine impu-rity F in ibuprofen and its preparations .