CAJ | 학술논문

目的：探讨XIAP（X-linked inhibitor of apoptosis protein，XIAP）和Smac（second mitochondria-derived activator of cas-pase，Smac）在非小细胞肺癌（non-small cell lung cancer，NSCLC）组织中的表达与临床病理特征及预后的关系。方法：采用免疫组织化学法检测70例非小细胞肺癌组织及70例对应癌旁肺组织中XIAP、Smac的表达。结果：XIAP在70例NSCLC组织中有59例阳性表达，其中高表达16例；对应70例癌旁肺组织中有52例表达，其中高表达5例，两组XIAP表达强度比较差异有统计学意义（Z=-4.049，P<0.001）；Smac在70例肺癌组织中有63例阳性表达，其中高（强阳性）表达32例；对应70例癌旁肺组织有53例表达，其中高（强阳性）表达5例，两组Smac表达强度比较差异有统计学意义（Z=-5.484，P<0.001）。NSCLC组织中XIAP、Smac的表达与患者的性别、年龄、肿瘤大小、组织类型、分化程度、吸烟与否等无明显关系（P>0.05）；但二者的表达均与临床分期、淋巴结转移与否有关系（P<0.05）。通过Kaplan-Meier法分析得出，XIAP和Smac在NSCLC中的表达与患者的预后均无明显关系（P>0.05）。结论：1）XIAP和Smac在非小细胞肺癌组织及其对应癌旁肺组织中均有表达，但存在表达量的差异。2）XIAP和Smac在非小细胞肺癌中的表达与患者的预后均无显著关系。
목적：탐토XIAP（X-linked inhibitor of apoptosis protein，XIAP）화Smac（second mitochondria-derived activator of cas-pase，Smac）재비소세포폐암（non-small cell lung cancer，NSCLC）조직중적표체여림상병리특정급예후적관계。방법：채용면역조직화학법검측70례비소세포폐암조직급70례대응암방폐조직중XIAP、Smac적표체。결과：XIAP재70례NSCLC조직중유59례양성표체，기중고표체16례；대응70례암방폐조직중유52례표체，기중고표체5례，량조XIAP표체강도비교차이유통계학의의（Z=-4.049，P<0.001）；Smac재70례폐암조직중유63례양성표체，기중고（강양성）표체32례；대응70례암방폐조직유53례표체，기중고（강양성）표체5례，량조Smac표체강도비교차이유통계학의의（Z=-5.484，P<0.001）。NSCLC조직중XIAP、Smac적표체여환자적성별、년령、종류대소、조직류형、분화정도、흡연여부등무명현관계（P>0.05）；단이자적표체균여림상분기、림파결전이여부유관계（P<0.05）。통과Kaplan-Meier법분석득출，XIAP화Smac재NSCLC중적표체여환자적예후균무명현관계（P>0.05）。결론：1）XIAP화Smac재비소세포폐암조직급기대응암방폐조직중균유표체，단존재표체량적차이。2）XIAP화Smac재비소세포폐암중적표체여환자적예후균무현저관계。
Objective:To investigate the expression of XIAP and Smac in human non-small-cell lung carcinoma (NSCLC) and the relationship with clinical significance and prognosis. Methods:Immunohistochemical staining was performed to determine the ex-pression of X-linked inhibitor of apoptosis protein (XIAP) and second mitochondria-derived activator of caspase (Smac) in 70 cases of NSCLC and 70 cases of non-cancerous adjacent lung tissues. Results:XIAP is mostly present (59/70) in tumor tissues with 16 high ex-pressions, whereas only five high expressions in non-cancerous adjacent lung tissues are observed (52/70). The statistical difference of these two sets of data is significant (Z=-5.484, P<0.001). Comparatively, Smac is present (63/70) in tumor tissues, which is significant-ly (Z=-5.484, P<0.001) higher than in the non-cancerous adjacent lung tissues (53/70). The expression levels of XIAP and Smac in NSCLC tissues are closely related to the lymph node metastasis at the TNM stages (P<0.05) and not associated to gender, age, size of tumor, and differentiation grades (P>0.05). The Kaplan-Meier analysis results show that survival by XIAP and Smac protein in NSCLC has no significant effect (P>0.05). Conclusion:XIAP and Smac are expressed in NSCLC and noncancerous adjacent lung tissues, and the differences in their expression levels is significant. The deterioration of NSCLC results in apoptosis/anti-apoptotic synchronized with tumor cell proliferation. The expression levels of XIAP and Smac in NSCLC are not related with the prognosis.