CAJ | 학술논문

目的探讨高渗盐水浸泡剥离法联合丝裂霉素C (MMC)手术治疗翼状胬肉的临床疗效和安全性.方法对2010年5月至2012年9月在赣南医学院第二附属医院眼科就诊的104例(124只眼)原发性翼状胬肉患者,按手术方法分为A、B两组:A组53例(64只眼)采用5％高渗盐水浸泡剥离法联合MMC的手术方式进行治疗,B组51例(60只眼)采用单纯性翼状胬肉切除术.术后随访12个月,比较两组患者术后复发率及创面角膜上皮修复时间.结果 A组64只眼中有5只眼复发,复发率为7.81％ (5/64);B组60只眼中有16只眼复发,复发率为26.67％ (16/60),两者比较差异有统计学意义(x2=7.8255,P=0.005).角膜创面上皮平均修复时间A组为(4.64±0.98)d,B组为(5.10±1.05)d,两者比较差异有统计学意义(t =2.514,P=0.013).两组均未出现严重并发症.结论高渗盐水浸泡剥离法联合MMC治疗原发性翼状胬肉,术后角膜创面修复快,胬肉复发率低,方法简便,安全有效,值得推广及应用.
목적 탐토고삼염수침포박리법연합사렬매소C (MMC)수술치료익상노육적림상료효화안전성.방법 대2010년5월지2012년9월재공남의학원제이부속의원안과취진적104례(124지안)원발성익상노육환자,안수술방법분위A、B량조:A조53례(64지안)채용5％고삼염수침포박리법연합MMC적수술방식진행치료,B조51례(60지안)채용단순성익상노육절제술.술후수방12개월,비교량조환자술후복발솔급창면각막상피수복시간.결과 A조64지안중유5지안복발,복발솔위7.81％ (5/64);B조60지안중유16지안복발,복발솔위26.67％ (16/60),량자비교차이유통계학의의(x2=7.8255,P=0.005).각막창면상피평균수복시간A조위(4.64±0.98)d,B조위(5.10±1.05)d,량자비교차이유통계학의의(t =2.514,P=0.013).량조균미출현엄중병발증.결론 고삼염수침포박리법연합MMC치료원발성익상노육,술후각막창면수복쾌,노육복발솔저,방법간편,안전유효,치득추엄급응용.
Objective To evaluate the effectiveness and safety of hypertonic saline (5％ sodium chloride) soaked peeling combined with mitomycin C (MMC) in the treatment of pterygium.Methods According to the operation method,104 cases (124 eyes) with primary pterygiums were divided into two groups:hypertonic saline soaked peeling combined with MMC group (group A,53 cases,64 eyes) and pure excision group (group B,51 cases,60 eyes).All cases were followed up for 12 months,and then compared the recurrence rate and epithelia recovering time of comeal wound.Results The recurrence rate was 7.81％ in group A,(5 of 64 eyes were recurred); the recurrence rate was 26.67％ in group B,(16 of 60 eyes were recurred),the difference between the two groups was statistically significant (x2=7.8255,P =0.005).The mean time of epithelial healing was (4.64±0.98) days in group A,while (5.10±1.05) days in group B,the difference of epithelial healing time between the two groups was statistically significant (t =2.514,P =0.013).No severe complications were found in two groups.Conclusions Hypertonic saline soaked peeling combined with MMC in the treatment of primary pterygium can decrease the recurrence rate,improve epithelia recovering time of corneal wound.It is simple,safe and effective,is worthy of promotion and application.