CAJ | 학술논문

本试验对恩诺沙星和硫酸丁胺卡那霉素在4种奶牛乳房炎常见病原菌（无乳链球菌、化脓链球菌、金黄色葡萄球菌、致病性大肠埃希氏菌）联合药敏试验中的相互作用进行了研究。结果表明，恩诺沙星和硫酸丁胺卡那霉素对各菌的MIC为8~64μg/mL，二者联合后的FIC指数范围为0.5~1，二者联合用药时为协同作用或相加作用。
본시험대은낙사성화류산정알잡나매소재4충내우유방염상견병원균（무유련구균、화농련구균、금황색포도구균、치병성대장애희씨균）연합약민시험중적상호작용진행료연구。결과표명，은낙사성화류산정알잡나매소대각균적MIC위8~64μg/mL，이자연합후적FIC지수범위위0.5~1，이자연합용약시위협동작용혹상가작용。
To study the interaction between enrolfoxacin and kanamycin against the bacteria of dairy cow mastitis, the susceptibility testing of drug combination to Streptococcus agalactiae, Streptococcus pyogenes, Staphylococcus aureus and E.coli in vitro was conducted. The minimal inhibitory concentration(MIC) of enrolfoxacin and kanamycin against the batertia was determined with the grade dilution method. The fractional inhibitory concentration(FIC) was measured with checkerboard microdilution method. The results showed MIC of enrolfoxacin and kanamycin against the batertia was 8~64μg/mL and the FIC of enrolfoxacin and kanamycin was 0.5~1. The study suggested that the combination of enrolfoxacin and kanamycin to Streptococcus agalactiae, Streptococcus pyogenes and E.coli had additive effect, and to Staphylococcus aureus demonstrated synergic action.