CAJ | 학술논문

目的：：探讨石韦不同溶剂提取物的抗炎镇痛作用。方法：制备石韦水提取物和75%乙醇提取物，采用二甲苯致小鼠耳廓肿胀法观察其抗炎作用，采用醋酸扭体法和热板法观察其镇痛作用。结果：石韦醇提取物能明显抑制二甲苯所致小鼠耳廓肿胀(P<0.01)，且具有抑制醋酸致小鼠扭体的作用(P<0.05)，在给药后1 h、2 h均能提高热板法小鼠的痛阈值(P<0.05)；石韦水提取物能抑制二甲苯所致小鼠耳廓肿胀和醋酸所致小鼠扭体的作用(P<0.05)，在给药后1 h能提高热板法小鼠的痛阈值(P<0.05)。结论：石韦具有一定的抗炎镇痛作用。
목적：：탐토석위불동용제제취물적항염진통작용。방법：제비석위수제취물화75%을순제취물，채용이갑분치소서이곽종창법관찰기항염작용，채용작산뉴체법화열판법관찰기진통작용。결과：석위순제취물능명현억제이갑분소치소서이곽종창(P<0.01)，차구유억제작산치소서뉴체적작용(P<0.05)，재급약후1 h、2 h균능제고열판법소서적통역치(P<0.05)；석위수제취물능억제이갑분소치소서이곽종창화작산소치소서뉴체적작용(P<0.05)，재급약후1 h능제고열판법소서적통역치(P<0.05)。결론：석위구유일정적항염진통작용。
Objective:To study the anti-inflammatory and analgesic effects of different solvent extracts of Folium Pyrrosiae. Meth-ods:Water extract and 75% alcohol extract of Folium Pyrrosiae were obtained. Mouse auricle swelling model induced by xylene was used to observe the anti-inflammation. The analgesic effect was tested by acetic acid writhing test and hot plate test. Results:The eth-anol extract of Folium Pyrrosiae could markedly inhibit the mouse auricle swelling induced by xylene (P<0. 01), and had the ability to inhibit the twisting induced by acetic acid in the mice (P <0. 05). The ethanol extract of Folium Pyrrosiae could increase the threshold of pain in the mice significantly after the 1-hour and 2-hour treatment (P<0. 05). The water extract of Folium Pyrrosiae could inhibit the mouse auricle swelling induced by xylene and the writhing reaction induced by acetic acid (P<0. 05). The water ex-tract of Folium Pyrrosiae could increase the threshold of pain in the mice significantly after the 1-hour treatment (P<0. 05). Conclu-sion:Folium Pyrrosiae has obvious analgesic and anti-inflammatory effects.