CAJ | 학술논문

目的：：研究龙蔓藤茶调节血脂的作用。方法：用高脂饲料喂养雄性SD大鼠,随机分为模型组、龙蔓藤茶高剂量组37.80 g·kg-1、中剂量组12.60 g·kg-1、低剂量组6.30 g·kg-1及降脂药物组(180 mg·kg-1),连续给药30 d,观察各组大鼠体质量、血清总胆固醇( TC )、三酰甘油( TG )、高密度脂蛋白( HDL-C )等指标的变化。结果：各给药组体质量增长与模型组比较,差异无统计学意义(P>0.05),大鼠未出现明显中毒症状；模型组实验后的TC和TG明显高于实验前(P<0.05)；给药30 d后,与模型组比较,龙蔓藤茶37.80 g·kg-1剂量组可显著降低高脂饲料大鼠血清TC和TG水平(P<0.05)。结论：龙蔓藤茶具有辅助降血脂的作用。
목적：：연구룡만등다조절혈지적작용。방법：용고지사료위양웅성SD대서,수궤분위모형조、룡만등다고제량조37.80 g·kg-1、중제량조12.60 g·kg-1、저제량조6.30 g·kg-1급강지약물조(180 mg·kg-1),련속급약30 d,관찰각조대서체질량、혈청총담고순( TC )、삼선감유( TG )、고밀도지단백( HDL-C )등지표적변화。결과：각급약조체질량증장여모형조비교,차이무통계학의의(P>0.05),대서미출현명현중독증상；모형조실험후적TC화TG명현고우실험전(P<0.05)；급약30 d후,여모형조비교,룡만등다37.80 g·kg-1제량조가현저강저고지사료대서혈청TC화TG수평(P<0.05)。결론：룡만등다구유보조강혈지적작용。
Objective:To study the effect of Longman Ampelopsis grossedentata on the level of serum lipid. Methods:The exper-imental rats were given high-fat diet during the experiment. The rats were randomly divided into the model group, high dose group (37. 80 g·kg-1), medium dose group (12. 60 g·kg-1), low dose group (6. 30 g·kg-1) and lipid-lowering drug group (180 mg· kg-1 ) . All the groups were administrated continuously for 30 days, and the effect on body weight, serum TC, TG and HDL-C were measured. Results:Compared with that of the model group, the increase of body weight in the other groups was not significant ( P>0. 05), and all the rats had no obvious poisoning symptom. TC and TG were higher after the high-fat diet administration than those be-fore the experiment in the model group, and the differences were statistically significant (P<0. 05). After the 30-day treatment, the levels of TC and TG in the high-dose group were significantly decreased compared with those of the model group (P<0. 05). Conclu-sion:Longman Ampelopsis grossedentata shows assistant therapeutic effect on serum lipid.