CAJ | 학술논문

目的：通过分别对胸腔积液病人CEA(癌胚抗原),NSE(神经元特异性烯醇化酶)、细胞角蛋白19片段的测定,以及三者联合检测的应用,来判断患者胸腔积液的良恶性的临床价值。方法对NSE、CEA和CYFRA21-1的检测采用电化学发光法。结果 CYFRA21-1灵敏度为63．16%,准确度为75．64%,You den指数为0．51,特异度为87．5%；NSE 的灵敏度为47．37%,准确度为66．67%,You den 指数为0．32,特异度为85%；CEA 灵敏度为60．53%,准确度为79．49%,You den 指数为0．58,特异度为97．5%。对于三者联合使用的结果中, CYFRA21-1和CEA联合检测的阳性率较高。结论肿瘤标志物在对恶性胸腔积液的诊断过程中,联合检测更有临床价值。
목적：통과분별대흉강적액병인CEA(암배항원),NSE(신경원특이성희순화매)、세포각단백19편단적측정,이급삼자연합검측적응용,래판단환자흉강적액적량악성적림상개치。방법대NSE、CEA화CYFRA21-1적검측채용전화학발광법。결과 CYFRA21-1령민도위63．16%,준학도위75．64%,You den지수위0．51,특이도위87．5%；NSE 적령민도위47．37%,준학도위66．67%,You den 지수위0．32,특이도위85%；CEA 령민도위60．53%,준학도위79．49%,You den 지수위0．58,특이도위97．5%。대우삼자연합사용적결과중, CYFRA21-1화CEA연합검측적양성솔교고。결론종류표지물재대악성흉강적액적진단과정중,연합검측경유림상개치。
Objective To evaluate the diagnostic value of combined test of CEA, CYFRA21-1 and NSE in differentiating benign or malignant pleural effusion. Methods The levels of pleural fluid CEA, NSE and CYFRA21-1 were detected by electro-chemiluminescence Immunoassay. Results The sensitivity of CEA was 60. 53%, 97. 5%of specificity, 0. 58 of Youden index,and 79. 49% of accuracy. The sensitivity of NSE was 47. 37%, 85. 00% of specificity, 0. 32 of Youden index, and 66. 67% of accuracy. The sensitivity of CYFRA21-1 was 63. 16%, 87. 5%of specificity, 0. 51 of Youden index, and 75. 64% of accuracy. The combined detection of CEA and CYFRA21-1 had the highest positive detection rate. Conclusion The combined detection of CEA and CYFRA21-1 has better val-ue in the diagnosis of malignant pleural effusion.