CAJ | 학술논문

目的：探讨放疗同期紫杉醇联合卡铂方案与序贯放化疗治疗局部晚期非小细胞肺癌( NSCLC)疗效及毒副反应。方法将60例局部晚期NSCLC患者随机分为放化同步组(同步组)和放化疗组(序贯组)各30例；两组均行适形放疗，化疗均为PC方案，同步组每周一次；序贯组每3周一次，化疗2周期后再行放疗。观察两组治疗近期有效率、生存率及急性毒副反应。结果两组均完成放化疗，同步组总有效率86.67%，序贯组63．33%(P<0．05)；3~4级骨髓抑制发生率同步组为30．0%，序贯组为23．3%；同步组和序贯组3~4级放射性肺炎发生率分别为13．4%和6．7%(P<0．05)；均可耐受。结论同步放化疗能够显著提高局部晚期NSCLC生存率，急性毒副反应均可耐受。
목적：탐토방료동기자삼순연합잡박방안여서관방화료치료국부만기비소세포폐암( NSCLC)료효급독부반응。방법장60례국부만기NSCLC환자수궤분위방화동보조(동보조)화방화료조(서관조)각30례；량조균행괄형방료，화료균위PC방안，동보조매주일차；서관조매3주일차，화료2주기후재행방료。관찰량조치료근기유효솔、생존솔급급성독부반응。결과량조균완성방화료，동보조총유효솔86.67%，서관조63．33%(P<0．05)；3~4급골수억제발생솔동보조위30．0%，서관조위23．3%；동보조화서관조3~4급방사성폐염발생솔분별위13．4%화6．7%(P<0．05)；균가내수。결론동보방화료능구현저제고국부만기NSCLC생존솔，급성독부반응균가내수。
Objective To evaluate the curative effect and side effect of RT combined with PC concurrent chemotherapy in the treatment of locally advanced NSCLC. Methods 60 patients with locally advanced non-small cell lung cancer were divided into two groups and treated with radiotherapy, 30 patients in the concurrent group and 30 in the sequential group. Response rate and adverse reactions were evaluated. Results The overall response rate ( CR+PR) was 86. 67% and 63. 33% respectively in the concurrent group and the sequential group ( P<0. 05 ) . The incidence of bone marrow depression was 30% and 23. 3% and the occurrence of radiation pneumonia was 13. 4% and 6. 7% respectively in the concurrent group and the sequential group. Conclusion Concurrent chemora-diotherapy is well tolerated and can improve response rate in most patients with locally advanced non-small cell lung cancer.