CAJ | 학술논문

目的：了解南京地区胸科医院结核病患者结核分枝杆菌对临床常用9种药物的耐药情况。方法对我院分离的结核分枝杆菌采用绝对浓度法对9种抗结核药物：链霉素、异烟肼、乙胺丁醇、利福平、对氨基水杨酸、丁胺卡那霉素、卷曲霉素、左氧氟沙星、对氨基水杨酸异烟肼进行药敏试验，同时用PNB、TCH进行菌种初步鉴定。结果10014株结核分枝杆菌中，总耐药率38．42%(3847/10014)，单耐药率最高为利福平(27．35%)，最低为卷曲霉素(0．50%)；2017株耐多药结核分枝杆菌对另外7种药物单耐药率最高为链霉素(56．22%)，最低为卷曲霉素(1．69%)，对9种药物全耐者有3株。结论结核分枝杆菌对多种药物耐药率高，应加强抗结核药物耐药性监测，根据药敏试验结果选择科学有效的化疗方案。
목적：료해남경지구흉과의원결핵병환자결핵분지간균대림상상용9충약물적내약정황。방법대아원분리적결핵분지간균채용절대농도법대9충항결핵약물：련매소、이연정、을알정순、리복평、대안기수양산、정알잡나매소、권곡매소、좌양불사성、대안기수양산이연정진행약민시험，동시용PNB、TCH진행균충초보감정。결과10014주결핵분지간균중，총내약솔38．42%(3847/10014)，단내약솔최고위리복평(27．35%)，최저위권곡매소(0．50%)；2017주내다약결핵분지간균대령외7충약물단내약솔최고위련매소(56．22%)，최저위권곡매소(1．69%)，대9충약물전내자유3주。결론결핵분지간균대다충약물내약솔고，응가강항결핵약물내약성감측，근거약민시험결과선택과학유효적화료방안。
Objective To analyze the drug resistance of mycobacterium tuberculosis ( MTB) for 9 type anti-tuberculosis drugs in Nanjing chest Hospital. Methods MTB strains were tested with absolute concentration method for 9 type anti-tuberculosis drugs, including SM, INH, EMB, RFP, PAS, AMK, CPM, LVFX and PSNZ. Results The total ratio of drug resistance for 9 type anti-tuberculosis drugs was 38. 42% (3847/10014). The highest re-sistant rate was RFP (27. 35%), and the lowest was CPM (0. 50%). Of 2017 strains multidrug resistant tuberculo-sis (MDR-TB), the highest resistant rate was SM (56. 22%), and the lowest was CPM (1. 69%). There were 3 strains of MDR-TB resistant to another 7 type anti-tuberculosis drugs. Conclusion MTB is highly resistant to a vari-ety of antibiotics. Monitoring of resistance to anti-tuberculosis drugs must be strengthened.