CAJ | 학술논문

目的：探讨血清降钙素原( PCT)在COPD急性加重期( AECOPD)优化抗生素应用中的价值。方法80例患者随机分为观察组和对照组各40例，对照组根据经验使用抗生素，观察组根据血清PCT水平指导抗生素应用。结果两组有效率、住院时间及住院病死率相似(P>0．05)；观察组抗菌药物疗程、住院费用及二重感染率均低于对照组，差异存在显著性(P<0．05)。治疗两周后患者功能状态评分较本组治疗前明显降低(P<0．05)，但是两组间比较，差异无显著性(P>0．05)。结论 PCT具有指导AECOPD抗生素治疗的作用，有效防止抗生素过度使用。
목적：탐토혈청강개소원( PCT)재COPD급성가중기( AECOPD)우화항생소응용중적개치。방법80례환자수궤분위관찰조화대조조각40례，대조조근거경험사용항생소，관찰조근거혈청PCT수평지도항생소응용。결과량조유효솔、주원시간급주원병사솔상사(P>0．05)；관찰조항균약물료정、주원비용급이중감염솔균저우대조조，차이존재현저성(P<0．05)。치료량주후환자공능상태평분교본조치료전명현강저(P<0．05)，단시량조간비교，차이무현저성(P>0．05)。결론 PCT구유지도AECOPD항생소치료적작용，유효방지항생소과도사용。
Objective To investigate the value of procalcitonin ( PCT) in optimization of antibiotics applica-tion in AECOPD patients. Methods 80 patients were selected and randomly divided into the observation group and the control group, 40 patients in each group. The control group used antibiotics according to the doctors′experiences, while the observation group used antibiotics according to serum PCT level. Results There was no significant differ-ence in clinical effective rate and duration of hospital stay (P>0. 05). But the course of antibacterial treatment, the cost of hospital stay and incidence of dual infection was significantly lower in the observation group than in the control group (P<0. 05). 2 weeks after the treatment, the functional status scores in the two groups decreased significantly when compared with those before the treatments (P<0. 05), but the difference between the two groups showed no statistical significance (P>0. 05). Conclusion PCT can guide the use of antibiotics, which can effectively prevent from excessive use of antibiotics.