CAJ | 학술논문

目的：研究血清降钙素原( PCT)检测在慢性阻塞性肺疾病急性加重期( AECOPD)对使用抗生素的指导价值。方法选取收治的AECOPD患者63例,随机分配成两组：PCT指导治疗组32例(简称 PCT组)和常规治疗组31例(简称对照组),检测血清PCT水平。在常规治疗的基础上,对照组按照临床抗生素使用指南决定抗生素疗程,PCT组按照血清PCT水平决定抗生素的使用,当血清PCT≥0．25ng/mL时,进行抗生素治疗,当PCT<0.25 ng/mL时,则停止使用抗生素。并观察两组患者抗生素的使用疗程,抗生素所用费用及住院时间。结果 PCT组抗生素疗程[7(5~11)d]短于对照组[13(7~16)d](P=0．03)；PCT组抗生素费用低于对照组(P=0．001),两组的住院时间及预后无明显差异。结论 AECOPD患者根据PCT水平使用抗生素,能够明显缩短抗生素的所用疗程,减少医疗费用。
목적：연구혈청강개소원( PCT)검측재만성조새성폐질병급성가중기( AECOPD)대사용항생소적지도개치。방법선취수치적AECOPD환자63례,수궤분배성량조：PCT지도치료조32례(간칭 PCT조)화상규치료조31례(간칭대조조),검측혈청PCT수평。재상규치료적기출상,대조조안조림상항생소사용지남결정항생소료정,PCT조안조혈청PCT수평결정항생소적사용,당혈청PCT≥0．25ng/mL시,진행항생소치료,당PCT<0.25 ng/mL시,칙정지사용항생소。병관찰량조환자항생소적사용료정,항생소소용비용급주원시간。결과 PCT조항생소료정[7(5~11)d]단우대조조[13(7~16)d](P=0．03)；PCT조항생소비용저우대조조(P=0．001),량조적주원시간급예후무명현차이。결론 AECOPD환자근거PCT수평사용항생소,능구명현축단항생소적소용료정,감소의료비용。
Objective To investigate the guidance value of procalcitonin on antibiotic use in the treatment of AECOPD patients. Methods 63 patients with AECOPD were randomly divided into the PCT group (n=32) and the control group (n=31). The serum concentration of procalcitonin (PCT) were measured in all patients. On the base of similar routine treatment, the control group received antibiotics based on the physician 's decision, and the PCT group were treated with antibiotics according to serum PCT levels. The antibiotic treatment was applied when the level of PCT was higher than 0. 25ng/mL and stopped when the level of PCT was lower than 0. 25ng/mL. The duration of antibiotics use and hospital stay was observed. Results The duration of antibiotics use was shorter in the PCT group [7(5~11)d] than in the control group [13(7~16)d] (P=0. 03), and the cost of antibiotics in the PCT group was lower than that in the control group (P=0. 001). There was no significant difference in clinical efficacy and du-ration of hospital stay in the two groups (P>0. 05). Conclusion PCT guidance can reduce antibiotic duration and antibiotic cost in the treatment of AECOPD patients.