CAJ | 학술논문

鲍曼不动杆菌是目前引起院内感染的重要条件致病菌之一，严重影响患者的生命安全。鲍曼不动杆菌特殊的基因结构导致其对多种临床抗生素产生高度耐药性，使其感染时可供选择的药物受限，且临床疗效相对较差。因而，现阶段必须明确鲍曼不动杆菌产生耐药性的机制，选择合理有效的抗生素，并根据药敏结果调整治疗方案。鲍曼不动杆菌的耐药机制主要是耐药酶的产生、药物作用靶位的改变、药物“外排泵”的形成、外膜结构及蛋白数量的改变以及整合子的结构和基因改变。临床医师应当明确鲍曼不动杆菌对于各类药物产生耐药性的机制，及时掌握本地区的鲍曼不动杆菌流行特点及耐药性，合理应用抗生素，并注意对患者痰液实施复检，以控制耐药菌株的感染率。
포만불동간균시목전인기원내감염적중요조건치병균지일，엄중영향환자적생명안전。포만불동간균특수적기인결구도치기대다충림상항생소산생고도내약성，사기감염시가공선택적약물수한，차림상료효상대교차。인이，현계단필수명학포만불동간균산생내약성적궤제，선택합리유효적항생소，병근거약민결과조정치료방안。포만불동간균적내약궤제주요시내약매적산생、약물작용파위적개변、약물“외배빙”적형성、외막결구급단백수량적개변이급정합자적결구화기인개변。림상의사응당명학포만불동간균대우각류약물산생내약성적궤제，급시장악본지구적포만불동간균류행특점급내약성，합리응용항생소，병주의대환자담액실시복검，이공제내약균주적감염솔。
acinetobacter baumanni is currently one of the most important pathogens of nosocomial infection, serious influence patient's life. Acinetobacter baumanni special genetic structure, leading to its high resistance for a variety of clinical antibiotics, the infection when limited selection of drugs, and clinical curative effect is relatively poor. Therefore, the present stage must be explicitly acinetobacter baumanni resistant mechanism, choose reasonable and effective antibiotics, and adjust the treatment according to the results of the drug susceptibility. Mechanism of drug resistance of acinetobacter baumanni mainly resistant enzyme production, the change of drug action, the formation of drug efflux pump ", and the outer membrane protein structure and quantity change and integration of sub structures and genetic changes. Clinical doctors should clear acinetobacter baumanni for al kinds of drug resistant mechanism, timely grasp the region of acinetobacter baumanni epidemic characteristics and drug resistance, reasonable use of antibiotics, and the note in patients' sputum, to control the infection rate of the drug resistant strains.