中外健康文摘
中外健康文摘
중외건강문적
WORLD HEALTH DIGEST
2014年
9期
143-143,144
,共2页
癌症%肿瘤标志物%ROC曲线%早期诊断
癌癥%腫瘤標誌物%ROC麯線%早期診斷
암증%종류표지물%ROC곡선%조기진단
Cancer%Tumor markers%ROC curve%Early diagnosis
目的：分析癌症患者肿瘤标记物浓度水平和诊断价值，并应用受试者工作特性（ROC）曲线确定肿瘤标记物联合检测的诊断阈值，评价诊断效果。方法：采集90例癌症患者和40例健康体检者空腹血，检测甲胎蛋白（AFP）、糖类抗原125（CA125）、糖类抗原19-9（CA19-9）、糖类抗原72-4（CA72-4）、癌胚抗原（CEA）、细胞角蛋白19（CYFRA21-1）、铁蛋白（FER）、神经元特异烯醇化酶（NSE）的血清水平，选取两组中具有非常显著的统计学意义差异(P<0.01)的项目应用SPSS19.0软件绘制ROC曲线，确定联合检测的诊断阈值，通过ROC曲线下面积(AUC)来评价肿瘤标志物联合检测的诊断效果。结果：AFP、CA125、CA72-4、CEA、CYFRA21-1高于正常对照组（P<0.01），以大于正常对照组中值为阳性条件绘制ROC曲线，AUC=0.80，当诊断阈值为阳性数2.5时，敏感度为65.6%，特异性为82.5%，均较高。结论：癌症患者伴有肿瘤标志物指标的不同程度的变化，AFP、CA125、CA72-4、CEA、CYFRA21-1联合检测可能提高常见癌症的诊断效果。
目的：分析癌癥患者腫瘤標記物濃度水平和診斷價值，併應用受試者工作特性（ROC）麯線確定腫瘤標記物聯閤檢測的診斷閾值，評價診斷效果。方法：採集90例癌癥患者和40例健康體檢者空腹血，檢測甲胎蛋白（AFP）、糖類抗原125（CA125）、糖類抗原19-9（CA19-9）、糖類抗原72-4（CA72-4）、癌胚抗原（CEA）、細胞角蛋白19（CYFRA21-1）、鐵蛋白（FER）、神經元特異烯醇化酶（NSE）的血清水平，選取兩組中具有非常顯著的統計學意義差異(P<0.01)的項目應用SPSS19.0軟件繪製ROC麯線，確定聯閤檢測的診斷閾值，通過ROC麯線下麵積(AUC)來評價腫瘤標誌物聯閤檢測的診斷效果。結果：AFP、CA125、CA72-4、CEA、CYFRA21-1高于正常對照組（P<0.01），以大于正常對照組中值為暘性條件繪製ROC麯線，AUC=0.80，噹診斷閾值為暘性數2.5時，敏感度為65.6%，特異性為82.5%，均較高。結論：癌癥患者伴有腫瘤標誌物指標的不同程度的變化，AFP、CA125、CA72-4、CEA、CYFRA21-1聯閤檢測可能提高常見癌癥的診斷效果。
목적：분석암증환자종류표기물농도수평화진단개치，병응용수시자공작특성（ROC）곡선학정종류표기물연합검측적진단역치，평개진단효과。방법：채집90례암증환자화40례건강체검자공복혈，검측갑태단백（AFP）、당류항원125（CA125）、당류항원19-9（CA19-9）、당류항원72-4（CA72-4）、암배항원（CEA）、세포각단백19（CYFRA21-1）、철단백（FER）、신경원특이희순화매（NSE）적혈청수평，선취량조중구유비상현저적통계학의의차이(P<0.01)적항목응용SPSS19.0연건회제ROC곡선，학정연합검측적진단역치，통과ROC곡선하면적(AUC)래평개종류표지물연합검측적진단효과。결과：AFP、CA125、CA72-4、CEA、CYFRA21-1고우정상대조조（P<0.01），이대우정상대조조중치위양성조건회제ROC곡선，AUC=0.80，당진단역치위양성수2.5시，민감도위65.6%，특이성위82.5%，균교고。결론：암증환자반유종류표지물지표적불동정도적변화，AFP、CA125、CA72-4、CEA、CYFRA21-1연합검측가능제고상견암증적진단효과。
To analyze the levels and diagnostic value of detecting indicators of tumor markers test in cancer patients, the diagnostic cutoff value of the combined detection of tumor markers was confirmed with ROC curve , the diagnostic effect in the common cancers based on the combined detection was evaluated. Methods: We col ected the fasting blood of 90 cases cancer patients and 40 cases people conducted health examination. AFP, CA125, CA19-9, CA72-4, CEA, CYFRA21-1, FER, NSE were detected by Roche E411 electrochemical immunodetection analyzer with intravenous serum. ROC curve were drawn with the selected indicators with a very significant statistical difference (P<0.01) in the two groups by SPSS 19.0 software. The diagnostic cutoff value of the combined detection of tumor markers was confirmed with ROC curve and the diagnostic effects of indicators were evaluated with AUC.Results:The levels of AFP, CA125, CA72-4, CEA, CYFRA21-1 in cancer group were more than those in the normal control group (P<0.01).With the corresponding medians of the normal control group as reference, combined detection of AFP, CA125, CA72-4, CEA, CYFRA21-1, AUC was 0.80. When the cutoff value was 2.5 positive items, the sensitivity was 65.6% and the specificity was 82.5% , respectively in a higher level.Conclusion: There were variations in indicators of tumor markers test in cancer patients to different extents. It is possible that the combined detection with tumor markers indicators of AFP, CA125, CA72-4, CEA, CYFRA21-1, could improve the diagnostic effects in the common cancer.
