CAJ | 학술논문

目的：观察玻璃酸钠联合唑来膦酸治疗绝经后妇女骨关节炎伴骨质疏松症的疗效。方法将98例确诊为骨关节炎伴骨质疏松症的患者随机平均分为2组，A组为对照组，关节腔内注射玻璃酸钠2.5 mL，每周1次，5周1个疗程；B组为试验组，除了使用玻璃酸钠外，加用唑来膦酸（密固达）治疗，对患者进行膝关节功能评分、VAS、BMD，结果进行统计分析。结果膝关节功能评分2组间差异无统计学意义（P＞0.05），膝关节疼痛缓解B组优于A组（P＜0.05），骨密度检测A组治疗前后无明显变化，B组较治疗前明显增加（P＜0.05）。结论采用膝关节腔内注射玻璃酸钠加唑来膦酸治疗绝经后妇女骨关节炎伴骨质疏松症患者，效果良好。
목적：관찰파리산납연합서래련산치료절경후부녀골관절염반골질소송증적료효。방법장98례학진위골관절염반골질소송증적환자수궤평균분위2조，A조위대조조，관절강내주사파리산납2.5 mL，매주1차，5주1개료정；B조위시험조，제료사용파리산납외，가용서래련산（밀고체）치료，대환자진행슬관절공능평분、VAS、BMD，결과진행통계분석。결과슬관절공능평분2조간차이무통계학의의（P＞0.05），슬관절동통완해B조우우A조（P＜0.05），골밀도검측A조치료전후무명현변화，B조교치료전명현증가（P＜0.05）。결론채용슬관절강내주사파리산납가서래련산치료절경후부녀골관절염반골질소송증환자，효과량호。
Objective To observe the treatment of sodium hyaluronate combined with zoledronic acid for the postmenopausal women with osteoporosis and osteoarthritis. Methods A total of 98 patients,who were diagnosed as osteoarthritis with osteoporosis ,were randomly divided into 2 groups. Group A was control group,the patients were given intraarticular injection of 2.5 mL sodium hyaluronate to the knee ,once a week for 5 weeks. Group B was the experimental group,the patients were given the treatment of zoledronic acid,they all received the treatment of sodium hyaluronate . Lysholm knee scoring, joint pain intensity evaluation( VAS),and bone mineral density( BMD)detection of the lumbar vertebrae of patients in both groups were performed before and after the treatment.Results Lysholm score of patients was no significant difference between the two groups(P> 0.05).The situation of knee pain in group B was better than that in group A(P<0.05).BMD in group A did not change significantly,and BMD of the lumbar vertebrae in group B increased obviously(P<0.05).Conclusion The treatment of sodium hyaluronate combined with zoledronic acid for the postmenopausal women with osteoporosis and osteoarthritis can obtain good effect.