CAJ | 학술논문

目的：观察拉米夫定治疗乙型肝炎肝硬化的临床疗效和安全性。方法选择我院2013年1月-2013年12月乙型肝炎肝硬化患者120例，随机分为对照组（60例）和治疗组（60例）。对照组给予常规保肝治疗，观察组在常规治疗的基础上加用拉米夫定（100m g/d），疗程为1年。比较观察比较、观察两组患者肝功能、Child-Pugh 评分、HBV-DNA转阴率、肝纤维化指标(HA、LN、PⅢP、Ⅳ-C)的变化。结果对照组、治疗组总有效率分别为61.67%、86.67%，两者之间有统计学差异(P＜0.05)。治疗组患者治疗1年后肝功能、肝纤维化指标、Child-Pugh 评分及HBV DNA阴转率均较对照组显著改善(P＜0.05)。结论拉米夫定治疗乙型肝炎肝硬化的临床效果肯定，可以延缓病情进展。
목적：관찰랍미부정치료을형간염간경화적림상료효화안전성。방법선택아원2013년1월-2013년12월을형간염간경화환자120례，수궤분위대조조（60례）화치료조（60례）。대조조급여상규보간치료，관찰조재상규치료적기출상가용랍미부정（100m g/d），료정위1년。비교관찰비교、관찰량조환자간공능、Child-Pugh 평분、HBV-DNA전음솔、간섬유화지표(HA、LN、PⅢP、Ⅳ-C)적변화。결과대조조、치료조총유효솔분별위61.67%、86.67%，량자지간유통계학차이(P＜0.05)。치료조환자치료1년후간공능、간섬유화지표、Child-Pugh 평분급HBV DNA음전솔균교대조조현저개선(P＜0.05)。결론랍미부정치료을형간염간경화적림상효과긍정，가이연완병정진전。
Objective: to observe the clinical curative effect of lamivudine treatment in hepatitis b cirrhosis of the liver, and security. Methods: from January 2013 - December 2013, 120 patients with hepatitis b cirrhosis of the liver were randomly divided into control group (60 cases) and treatment group (60 cases). Control group given conventional treatment, protect liver group on the basis of conventional treatment combined with lamivudine (100 mg/d), treatment for one year. Comparative observation comparison, observe two groups of patients with liver function, Child-Pugh score, HBV-DNA turn rate and liver fibrosis index (HA, LN, P Ⅲ P, Ⅳ-C). Results: the control group, treatment group total effectiveness 61.67%, 86.67% respectively, the difference between the two (P<0.05). Treatment group 1 year after treatment in patients with liver function and liver fibrosis index, Child - Pugh score and HBV DNA negative transfer rate than the control group improved significantly (P<0.05). Conclusion: the clinical effect of lamivudine treatment for hepatitis b liver cirrhosis, certainly can slow disease progression.