CAJ | 학술논문

目的：探讨脑小血管闭塞（ SAO）患者认知功能障碍的特点。方法临床收集110例患者和50例正常对照人群，根据MRI T2加权像和FLAIR像将病例组分为单纯性腔隙性脑梗死（ ILI）组和缺血性白质疏松（ILA）组，分别进行简明精神状态量表（MMSE）、蒙特利尔认知评估量表（MoCA）。结果①与对照组比较，ILI组和ILA组患者的MMSE和MoCA评分均明显低（ P＜0．05）；②与对照组比较， ILI组患者注意计算、短程记忆、图形描画评分显著降低（ P＜0．05）；ILA组患者时间定向、注意计算、短程记忆、语言理解和图形描画评分显著降低（ P＜0．05）。结论①脑小血管病变，可导致认知功能下降，ILA时最为显著；②ILA组患者主要表现为执行功能、视空间功能、注意计算、短程记忆等认知方面的障碍。
목적：탐토뇌소혈관폐새（ SAO）환자인지공능장애적특점。방법림상수집110례환자화50례정상대조인군，근거MRI T2가권상화FLAIR상장병례조분위단순성강극성뇌경사（ ILI）조화결혈성백질소송（ILA）조，분별진행간명정신상태량표（MMSE）、몽특리이인지평고량표（MoCA）。결과①여대조조비교，ILI조화ILA조환자적MMSE화MoCA평분균명현저（ P＜0．05）；②여대조조비교， ILI조환자주의계산、단정기억、도형묘화평분현저강저（ P＜0．05）；ILA조환자시간정향、주의계산、단정기억、어언리해화도형묘화평분현저강저（ P＜0．05）。결론①뇌소혈관병변，가도치인지공능하강，ILA시최위현저；②ILA조환자주요표현위집행공능、시공간공능、주의계산、단정기억등인지방면적장애。
Objective To investigate the change of cognitive function in the patients with small artery occlusion ( SAO) .Methods 110 patients were classified into group with isolated lacunar infarction ( ILI) , and group with ischaemic leukoaraiosis (ILA) according to MRI T2 images and FLAIR images.50normal persons as control group.All subjects'cognitive status were assessed with mini-mental state examination ( MMSE ) and Montreal Congnitive Assessment ( MoCA ) .Results The scores of MMSE and MoCA in the patients with SVD were significantly less than that in the control group (P<0.05); Compared with the control group, account ability,short term memory and graphics portrayed score decreased significantly in ILI group ( P<0.05); time orientation, account ability, short term memory , language understanding and graphics portrayed score decreased significantly in ILA group (P<0.05).Conclusion Cerebral small artery occlusion leads to cognitive decline especially in patients with ILA;cognitive declines such as executive function , visual-spatial function , account ability , short term memory are more popular .