CAJ | 학술논문

目的：从遗传毒理学方面了解并评价磁性纳米多孔复合（Nano-HA/PLLA/Fe2O3）材料的生物相容性，从而为其在移植肌腱固定的临床运用提供依据。方法：用Nano-HA/PLLA/Fe2O3磁性纳米复合界面固定材料制备混悬液，进行Ames致突变试验，以检测其对鼠伤寒沙门菌的致突变比值（实验组回变菌落数/阴性对照组回变菌落数）。结果：此人工骨材料的各浓度组混悬液对鼠伤寒沙门菌的致突变比值均小于2。结论：Nano-HA/PLLA/Fe2O3磁性纳米复合界面固定材料不引起鼠伤寒沙门菌的回复突变数增加，说明此材料无致基因突变性。
목적：종유전독이학방면료해병평개자성납미다공복합（Nano-HA/PLLA/Fe2O3）재료적생물상용성，종이위기재이식기건고정적림상운용제공의거。방법：용Nano-HA/PLLA/Fe2O3자성납미복합계면고정재료제비혼현액，진행Ames치돌변시험，이검측기대서상한사문균적치돌변비치（실험조회변균락수/음성대조조회변균락수）。결과：차인공골재료적각농도조혼현액대서상한사문균적치돌변비치균소우2。결론：Nano-HA/PLLA/Fe2O3자성납미복합계면고정재료불인기서상한사문균적회복돌변수증가，설명차재료무치기인돌변성。
Objective To evaluate the bio-compatibility and safety of the magnetic composite(Nano-HA/PLLA/Fe2O3) from the aspects of inherited toxicology of it for the clinical use of interface fixation.Methods Produce Nano-HA/PLLA/Fe2O3 magnetic composites material and it’s diffusion and test the diffusion through Ames test.The observation markers of the test are the mutagenes rates of murine typhoid salmonel a (MR). Results The mutagenesis rates of murine typhoid saline monel a in the experimental groups of al dosage levers are less than 2. Conclusion The magnetic composites material wil not cause the increase of the back mutation in murine typhoid salmonel a which show that this artificial bone wil not cause gene mutation.