新医学
新醫學
신의학
NEW CHINESE MEDICINE
2014年
10期
656-658
,共3页
王金林%张健杰%邓立华%邱少宏%唐玉宏%司徒洁%钦卓辉%韦始亮%李辉%李智民
王金林%張健傑%鄧立華%邱少宏%唐玉宏%司徒潔%欽卓輝%韋始亮%李輝%李智民
왕금림%장건걸%산립화%구소굉%당옥굉%사도길%흠탁휘%위시량%리휘%리지민
三氯乙烯药疹样皮炎%游离三碘甲状腺原氨酸%游离四碘甲状腺原氨酸%促甲状腺素
三氯乙烯藥疹樣皮炎%遊離三碘甲狀腺原氨痠%遊離四碘甲狀腺原氨痠%促甲狀腺素
삼록을희약진양피염%유리삼전갑상선원안산%유리사전갑상선원안산%촉갑상선소
Trichloroethylene-induced medicamentosa-like dermatitis%Free triiodothyronine%Free thyroxine%Thyrotropin
目的:观察三氯乙烯药疹样皮炎患者血清甲状腺激素水平的变化。方法选择2009年1月至2013年12月住院治疗的三氯乙烯药疹样皮炎患者65例作为研究对象,选取同期正常体检人员65名作为对照组。化学发光法检测所有研究对象血清中 TSH、FT3、FT43项甲状腺功能指标;统计所有三氯乙烯药疹样皮炎患者的激素使用总剂量。结果三氯乙烯药疹样皮炎患者血清甲状腺素水平均明显低于健康对照组:FT3(2.86±1.56 vs.4.70±0.92 pmol/L)、FT4(8.86±5.15 vs.16.07±3.02 pmol/L)、TSH (1.23±1.28 vs.2.71±1.35 mIu/l),P 均<0.01。三氯乙烯药疹样皮炎患者中高剂量激素组甲状腺激素水平明显低于低剂量激素组:FT3(1.39±0.81 vs.1.39±0.81 pmol/L)、FT4(4.12±2.83 vs.11.81±3.92 pmol/L)、TSH (0.41±0.15 vs.1.75±1.40 mIu/l),P 均<0.01。结论三氯乙烯药疹样皮炎患者甲状腺素水平明显降低,三氯乙烯药疹样皮炎患者测定甲状腺激素水平有助于判断疾病严重程度和预后。
目的:觀察三氯乙烯藥疹樣皮炎患者血清甲狀腺激素水平的變化。方法選擇2009年1月至2013年12月住院治療的三氯乙烯藥疹樣皮炎患者65例作為研究對象,選取同期正常體檢人員65名作為對照組。化學髮光法檢測所有研究對象血清中 TSH、FT3、FT43項甲狀腺功能指標;統計所有三氯乙烯藥疹樣皮炎患者的激素使用總劑量。結果三氯乙烯藥疹樣皮炎患者血清甲狀腺素水平均明顯低于健康對照組:FT3(2.86±1.56 vs.4.70±0.92 pmol/L)、FT4(8.86±5.15 vs.16.07±3.02 pmol/L)、TSH (1.23±1.28 vs.2.71±1.35 mIu/l),P 均<0.01。三氯乙烯藥疹樣皮炎患者中高劑量激素組甲狀腺激素水平明顯低于低劑量激素組:FT3(1.39±0.81 vs.1.39±0.81 pmol/L)、FT4(4.12±2.83 vs.11.81±3.92 pmol/L)、TSH (0.41±0.15 vs.1.75±1.40 mIu/l),P 均<0.01。結論三氯乙烯藥疹樣皮炎患者甲狀腺素水平明顯降低,三氯乙烯藥疹樣皮炎患者測定甲狀腺激素水平有助于判斷疾病嚴重程度和預後。
목적:관찰삼록을희약진양피염환자혈청갑상선격소수평적변화。방법선택2009년1월지2013년12월주원치료적삼록을희약진양피염환자65례작위연구대상,선취동기정상체검인원65명작위대조조。화학발광법검측소유연구대상혈청중 TSH、FT3、FT43항갑상선공능지표;통계소유삼록을희약진양피염환자적격소사용총제량。결과삼록을희약진양피염환자혈청갑상선소수평균명현저우건강대조조:FT3(2.86±1.56 vs.4.70±0.92 pmol/L)、FT4(8.86±5.15 vs.16.07±3.02 pmol/L)、TSH (1.23±1.28 vs.2.71±1.35 mIu/l),P 균<0.01。삼록을희약진양피염환자중고제량격소조갑상선격소수평명현저우저제량격소조:FT3(1.39±0.81 vs.1.39±0.81 pmol/L)、FT4(4.12±2.83 vs.11.81±3.92 pmol/L)、TSH (0.41±0.15 vs.1.75±1.40 mIu/l),P 균<0.01。결론삼록을희약진양피염환자갑상선소수평명현강저,삼록을희약진양피염환자측정갑상선격소수평유조우판단질병엄중정도화예후。
Objective To observe the changes in the serum level of thyroid hormone in patients with trichloroethylene (TCE)-induced medicamentosa-like dermatitis.Methods Sixty five patients diagnosed with TCE-induced medicamentosa-like dermatitis were enrolled in this study between January 2009 and Decem-ber 201 3.Sixty five healthy subjects were used as normal controls.Serum levels of thyroid-stimulating hormone (TSH),free triiodothyronine (FT3 )and free thyroxine (FT4 )were measured using chemiluminescence meth-od.Total dose of steroid hormones administered for all patients with TCE-induced medicamentosa-like dermati-tis was statistically calculated.Results The serum levels of thyroid hormones in TCE-induced medicamentosa-like dermatitis patients were significantly lower than those in healthy controls:FT3 (2.86 ±1 .56 vs.4.70 ± 0.92 pmol/L),FT4 (8.86 ±5.1 5 vs.1 6.07 ±3.02 pmol/L)and TSH (1 .23 ±1 .28 vs.2.71 ±1 .35 mIu/L)(all P <0.01 ).The serum levels of thyroid hormones in the high-dose group were significantly lower com-pared with those in the low-dose group:FT3 (1 .39 ±0.81 vs.1 .39 ±0.81 pmol/L),FT4 (4.1 2 ±2.83 vs.1 1 .81 ±3.92 pmol/L)and TSH (0.41 ±0.1 5 vs.1 .75 ±1 .40 mIu/l)(all P <0.01 ).Conclusions The serum levels of thyroid hormones in TCE-induced medicamentosa-like dermatitis patients are significantly lower than those in healthy counterparts.Detection of thyroid hormone levels is beneficial to the evaluation of the se-verity and prognosis for this disease.