CAJ | 학술논문

目的：探讨冠状动脉粥样硬化性心脏病（冠心病）患者血清内脂素与磷酸化 c-jun、CD40L 及组织因子（TF）的关系。方法选择不稳定型心绞痛患者65例（UAP 组）、稳定型心绞痛（SAP）患者75例、对照组60例，采用 ELISA 方法测定血清内脂素、磷酸化 c-jun、TF 及组织因子途径抑制物（TFPI）浓度水平，采用流式细胞技术测定 CD40L 平均荧光强度。结果UAP 组患者血清内脂素、磷酸化 c-jun、CD40L、TF、TFPI 水平及 TF ／TFPI 值高于 SAP 组及对照组（P ＜0.05或 P ＜0.01）；SAP 组上述指标均高于对照组（P ＜0.05或 P ＜0.01）。线性相关分析显示冠心病患者血清内脂素水平与磷酸化 c-jun、CD40L、TF、TFPI 水平及 TF ／TFPI 值呈正相关（P 均＜0.01）。多重线性逐步回归分析表明冠心病患者血清内脂素水平与磷酸化 c-jun、CD40L、TF 水平呈独立正相关（P 均＜0.01）。结论血清内脂素水平升高可能促进炎症标志物磷酸化 c-jun、CD40L 及组织因子生成，影响冠心病发生、发展及预后。
목적：탐토관상동맥죽양경화성심장병（관심병）환자혈청내지소여린산화 c-jun、CD40L 급조직인자（TF）적관계。방법선택불은정형심교통환자65례（UAP 조）、은정형심교통（SAP）환자75례、대조조60례，채용 ELISA 방법측정혈청내지소、린산화 c-jun、TF 급조직인자도경억제물（TFPI）농도수평，채용류식세포기술측정 CD40L 평균형광강도。결과UAP 조환자혈청내지소、린산화 c-jun、CD40L、TF、TFPI 수평급 TF ／TFPI 치고우 SAP 조급대조조（P ＜0.05혹 P ＜0.01）；SAP 조상술지표균고우대조조（P ＜0.05혹 P ＜0.01）。선성상관분석현시관심병환자혈청내지소수평여린산화 c-jun、CD40L、TF、TFPI 수평급 TF ／TFPI 치정정상관（P 균＜0.01）。다중선성축보회귀분석표명관심병환자혈청내지소수평여린산화 c-jun、CD40L、TF 수평정독립정상관（P 균＜0.01）。결론혈청내지소수평승고가능촉진염증표지물린산화 c-jun、CD40L 급조직인자생성，영향관심병발생、발전급예후。
Objective To investigate the relationship between serum visfatin and phosphorylated c-Jun,CD40L and tissue factors (TF)in patients with coronary heart disease.Methods In total,200 sub-jects were enrolled in this study and divided into the control group(n =60),unstable(n =65)and stable angi-na groups(n =75 ).Serum visfatin,phosphorylated c-Jun,TF and tissue factor pathway inhibitor (TFPI) were measured using ELLSA,while the percentage of positive CD40L was quantified by flow cytometry.Re-sults The serum levels of visfatin,phosphorylated c-Jun,CD40L,TF,TFPI and the ratio of TF /TFPI in the stable angina group were significantly higher compared with those in the control group(P <0.05 or P <0.01 ).All these parameters in patients with unstable angina were significantly higher than their counterparts with stable angina (P <0.05 or P <0.01 ).Linear correlation analysis revealed that serum visfatin was positively correla-ted with phosphorylated c-Jun,CD40L,TF,TFPI and TF /TFPI (all P <0.01 ).Multiple linear stepwise re-gression analysis demonstrated that serum visfatin was independently and positively associated with phosphoryla-ted c-Jun,CD40L and TF(all P <0.01 ).Conclusion Hypervisfatinemia probably influences the incidence, development and prognosis of coronary heart disease by elevating the levels of phosphorylated c-Jun,CD40L and TF.