CAJ | 학술논문

目的：探讨奈达铂每周方案同期放疗治疗老年晚期鼻咽癌的疗效和不良反应。方法将100例老年局部晚期鼻咽癌患者随机分为单纯放疗组和同期放化疗组。前者行单纯放疗，后者行奈达铂每周同期放疗。观察2组患者的近期疗效、远期疗效和不良反应。结果单纯放疗组（ RT）和同期放化疗组（ CRT）3个月后，鼻咽部肿块残存率分别为18．00％（9／50）和16．00％（8／50），差异无统计学意义（P＞0．05）；颈部肿块残存率分别为18．00％（9／50）和8．00％（4／50），单纯放疗组明显高于同期放化疗组，差异有统计学意义（P＜0．05）。单纯放疗组（RT）和同期放化疗组（CRT）的1年生存率分别为92．00％和94．00％，4年生存率分别为70．00％和76．00％，差异均无统计学意义（ P＞0．05）。2组患者均有不同程度的口腔黏膜损伤，肠胃不良反应和白细胞减少。结论采用奈达铂每周同期放疗可提高老年局部晚期鼻咽癌的疗效，且毒性可控，患者可以耐受。
목적：탐토내체박매주방안동기방료치료노년만기비인암적료효화불량반응。방법장100례노년국부만기비인암환자수궤분위단순방료조화동기방화료조。전자행단순방료，후자행내체박매주동기방료。관찰2조환자적근기료효、원기료효화불량반응。결과단순방료조（ RT）화동기방화료조（ CRT）3개월후，비인부종괴잔존솔분별위18．00％（9／50）화16．00％（8／50），차이무통계학의의（P＞0．05）；경부종괴잔존솔분별위18．00％（9／50）화8．00％（4／50），단순방료조명현고우동기방화료조，차이유통계학의의（P＜0．05）。단순방료조（RT）화동기방화료조（CRT）적1년생존솔분별위92．00％화94．00％，4년생존솔분별위70．00％화76．00％，차이균무통계학의의（ P＞0．05）。2조환자균유불동정도적구강점막손상，장위불량반응화백세포감소。결론채용내체박매주동기방료가제고노년국부만기비인암적료효，차독성가공，환자가이내수。
Objective To investigate the therapeutic effects and side effects of nedaplatin weekly conformal radiotherapy in treatment of elderly patients with locally advanced nasopharyngeal carcinoma .Methods 100 cases of elderly patients with lo-cally advanced nasopharyngeal carcinoma were randomly divided into the radiotherapy group and concurrent radiotherapy group . The former received radiation therapy ,and the later received nedaplatin weekly conformal radiotherapy .The short-term efficacy, long-term efficacy and side effects of the 2 groups were observed .Results After 3 months of treatment ,the nasopharyngeal mass survival rate of RT group and CRT group were 18.00%(9/50) and 16.00%(8/50),there was no statistically significant differ-ence (P>0.05);neck lump survival rates of RT group and CRT group were 18.00%(9/50) and 8.00%(4/50),radiotherapy group was significantly higher than that of the concurrent radiotherapy group , the difference was statistically significant ( P <0.05).1-year survival rates of RT group and CRT group were 92.00%and 94.00%,and 4-year survival rates of RT group and CRT group were 70.00%and 76.00%,there was no statistically significant difference ( P>0.05).Conclusion Nedaplatin combined with radiotherapy in treatment of elderly patients with locally advanced nasopharyngeal carcinoma can improve efficacy with tolerable toxicities .