实用癌症杂志
實用癌癥雜誌
실용암증잡지
THE PRACTICAL JOURNAL OF CANCER
2014年
10期
1322-1323,1326
,共3页
陈静%郑玲%芮红兵%林珺芳%曾志勇%陈玉铃%陈君敏
陳靜%鄭玲%芮紅兵%林珺芳%曾誌勇%陳玉鈴%陳君敏
진정%정령%예홍병%림군방%증지용%진옥령%진군민
多发性骨髓瘤%高钙血症
多髮性骨髓瘤%高鈣血癥
다발성골수류%고개혈증
Multiple Myeloma%Hypercalcemia
目的:分析多发性骨髓瘤( MM)合并高钙血症的临床特征。方法回顾性分析96例MM的临床资料,比较分析MM合并高钙血症患者与未合并高钙血症患者的临床特征。结果96例MM患者中,16例(16.7%)血清钙水平>2.6 mmol/L,经血清白蛋白校正后,22例(22.9%)血钙水平>2.6 mmol/L,与未合并高钙血症的患者比较,合并高钙血症MM患者更易出现溶骨性损害(OR 2.3,95%CI 0.27-19.81)、肾功能损害(OR 2.12,95%CI 0.63-7.17)、高乳酸脱氢酶血症(OR 5.15,95% CI 1.34-19.81)、β2微球蛋白升高(OR 7.92,95% CI 0.45-140.54)、贫血(OR 1.27,95% CI 0.49-3.29)和ISS分期为Ⅲ期(OR 3.08,95%CI 1.01-9.37)。结论 MM合并高钙血症的发生率高,其发生可能与MM病情进展有关。
目的:分析多髮性骨髓瘤( MM)閤併高鈣血癥的臨床特徵。方法迴顧性分析96例MM的臨床資料,比較分析MM閤併高鈣血癥患者與未閤併高鈣血癥患者的臨床特徵。結果96例MM患者中,16例(16.7%)血清鈣水平>2.6 mmol/L,經血清白蛋白校正後,22例(22.9%)血鈣水平>2.6 mmol/L,與未閤併高鈣血癥的患者比較,閤併高鈣血癥MM患者更易齣現溶骨性損害(OR 2.3,95%CI 0.27-19.81)、腎功能損害(OR 2.12,95%CI 0.63-7.17)、高乳痠脫氫酶血癥(OR 5.15,95% CI 1.34-19.81)、β2微毬蛋白升高(OR 7.92,95% CI 0.45-140.54)、貧血(OR 1.27,95% CI 0.49-3.29)和ISS分期為Ⅲ期(OR 3.08,95%CI 1.01-9.37)。結論 MM閤併高鈣血癥的髮生率高,其髮生可能與MM病情進展有關。
목적:분석다발성골수류( MM)합병고개혈증적림상특정。방법회고성분석96례MM적림상자료,비교분석MM합병고개혈증환자여미합병고개혈증환자적림상특정。결과96례MM환자중,16례(16.7%)혈청개수평>2.6 mmol/L,경혈청백단백교정후,22례(22.9%)혈개수평>2.6 mmol/L,여미합병고개혈증적환자비교,합병고개혈증MM환자경역출현용골성손해(OR 2.3,95%CI 0.27-19.81)、신공능손해(OR 2.12,95%CI 0.63-7.17)、고유산탈경매혈증(OR 5.15,95% CI 1.34-19.81)、β2미구단백승고(OR 7.92,95% CI 0.45-140.54)、빈혈(OR 1.27,95% CI 0.49-3.29)화ISS분기위Ⅲ기(OR 3.08,95%CI 1.01-9.37)。결론 MM합병고개혈증적발생솔고,기발생가능여MM병정진전유관。
Objective To find out the clinical characteristics of multiple myeloma ( MM) complicated by hypercalce-mia.Methods Clinical characteristics of 96 MM patients complicated by hypercalcemia was retrospectively analyzed .Results Among 96 patients,16 (16.67%) patients had hypercalcemia .After correction by serum albumin ,22 (22.92%) patients had hypercalcemia .Compared with non-hypercalcemia patients ,patients with hypercalcemia were more likely to have bone disease ( OR 2.3,95%CI 0.27-19.81),renal dysfunction(OR 2.12,95% CI 0.63-7.17),anemia(OR 1.27,95% CI 0.49-3.29),high LDH levels(OR 5.15,95%CI 1.34-19.81),β2-microglobulin levels(OR 7.92,95%CI 0.45-140.54),and stage Ⅲ ISS(OR 3.08,95%CI 1.01-9.37).Conclusion Hypercalcemia is a frequent complication of MM and it is associated with disease pro-gression.