实用癌症杂志
實用癌癥雜誌
실용암증잡지
THE PRACTICAL JOURNAL OF CANCER
2014年
10期
1318-1321
,共4页
中药清胰汤%多西他赛%顺铂%中晚期胰腺癌
中藥清胰湯%多西他賽%順鉑%中晚期胰腺癌
중약청이탕%다서타새%순박%중만기이선암
Chinese medicine Qingyitang%Docetaxel%Cisplatin%Middle and advanced pancreatic cancer
目的：探究中药清胰汤联合西药治疗中晚期胰腺癌的临床效果。方法选择68例中晚期胰腺癌患者，按照随机数字表法分组为治疗组和对照组。对照组：采用多西他赛，75 mg／m2静脉滴注；顺铂，75 mg／m2静脉滴注化疗。治疗组：在对照组治疗基础上加用中药清胰汤治疗，1剂／天。观察2组患者治疗前后病情评分和实验室指标恢复时间以及临床症状、体征恢复时间、临床近期疗效、远期（6个月、1年、3年）疗效、不良反应情况。结果治疗前，2组患者A-PACHEⅡ评分比较，P＞0．05；治疗3 d、7 d、10 d后，治疗组APACHEⅡ评分分别为（7．02±1．21）分、（5．67±0．99）分、（4．52±0．75）分，对照组则分别为（7．04±1．19）分、（6．47±1．07）分、（5．48±0．98）分；与治疗前比较，均出现明显下降，P＜0．05；治疗3 d后，2组APACHEⅡ评分比较，P＞0．05；治疗7 d和10 d后，2组APACHEⅡ评分比较，P＜0．05。此外，2组患者实验室指标恢复时间以及临床症状、体征恢复时间、临床近远期疗效以及不良反应比较，P均＜0．05。结论相比单纯西药治疗中晚期胰腺癌来说，采用中药清胰汤联合西药治疗的临床效果更佳，且不良反应发生少，值得推广应用。
目的：探究中藥清胰湯聯閤西藥治療中晚期胰腺癌的臨床效果。方法選擇68例中晚期胰腺癌患者，按照隨機數字錶法分組為治療組和對照組。對照組：採用多西他賽，75 mg／m2靜脈滴註；順鉑，75 mg／m2靜脈滴註化療。治療組：在對照組治療基礎上加用中藥清胰湯治療，1劑／天。觀察2組患者治療前後病情評分和實驗室指標恢複時間以及臨床癥狀、體徵恢複時間、臨床近期療效、遠期（6箇月、1年、3年）療效、不良反應情況。結果治療前，2組患者A-PACHEⅡ評分比較，P＞0．05；治療3 d、7 d、10 d後，治療組APACHEⅡ評分分彆為（7．02±1．21）分、（5．67±0．99）分、（4．52±0．75）分，對照組則分彆為（7．04±1．19）分、（6．47±1．07）分、（5．48±0．98）分；與治療前比較，均齣現明顯下降，P＜0．05；治療3 d後，2組APACHEⅡ評分比較，P＞0．05；治療7 d和10 d後，2組APACHEⅡ評分比較，P＜0．05。此外，2組患者實驗室指標恢複時間以及臨床癥狀、體徵恢複時間、臨床近遠期療效以及不良反應比較，P均＜0．05。結論相比單純西藥治療中晚期胰腺癌來說，採用中藥清胰湯聯閤西藥治療的臨床效果更佳，且不良反應髮生少，值得推廣應用。
목적：탐구중약청이탕연합서약치료중만기이선암적림상효과。방법선택68례중만기이선암환자，안조수궤수자표법분조위치료조화대조조。대조조：채용다서타새，75 mg／m2정맥적주；순박，75 mg／m2정맥적주화료。치료조：재대조조치료기출상가용중약청이탕치료，1제／천。관찰2조환자치료전후병정평분화실험실지표회복시간이급림상증상、체정회복시간、림상근기료효、원기（6개월、1년、3년）료효、불량반응정황。결과치료전，2조환자A-PACHEⅡ평분비교，P＞0．05；치료3 d、7 d、10 d후，치료조APACHEⅡ평분분별위（7．02±1．21）분、（5．67±0．99）분、（4．52±0．75）분，대조조칙분별위（7．04±1．19）분、（6．47±1．07）분、（5．48±0．98）분；여치료전비교，균출현명현하강，P＜0．05；치료3 d후，2조APACHEⅡ평분비교，P＞0．05；치료7 d화10 d후，2조APACHEⅡ평분비교，P＜0．05。차외，2조환자실험실지표회복시간이급림상증상、체정회복시간、림상근원기료효이급불량반응비교，P균＜0．05。결론상비단순서약치료중만기이선암래설，채용중약청이탕연합서약치료적림상효과경가，차불량반응발생소，치득추엄응용。
Objective To explore the clinical effect of chinese medicine Qingyitang combined with western medicine for middle and advanced pancreatic cancer .Methods 68 cases of middle and advanced pancreatic cancer patients were divided into the treatment group and the control group according to random number table method .The control group received docetaxel 75 mg/m2 intravenous drip and cisplatin 75 mg/m2 intravenous drip .The treatment group received chinese medicine Qingyitang 1 agent/day on the basis of the control group .Disease score,laboratory indexes recovery time ,clinical symptoms,signs of recovery time, clinical effect of short-term and long-term (6-month,1-year,3-year),and adverse reactions of the 2 groups before and after treat-ment were observed.Results Before the treatment,APACHEⅡscores of the 2 groups were compared (P>0.05);3 d,7 d,10 d after treatment APACHEⅡscores of the treatment group were (7.02 ±1.21),(5.67 ±0.99),(4.52 ±0.75),and that of the control group were (7.04 ±1.19),(6.47 ±1.07),(5.48 ±0.98);Compared with before treatment,all decreased significantly (P<0.05);3 d after treatment,APACHEⅡscores of the 2 groups were compared (P>0.05);7 d and 10 after treatment,A-PACHEⅡscores of the 2 groups were compared (P<0.05).In addition,laboratory indexes recovery time,clinical symptoms, signs of recovery time,clinical effect and adverse reactions of the 2 groups were compared (P<0.05).Conclusion Compared with the simple western medicine treatment , chinese medicine Qingyitang combined with western medicine for middle and ad-vanced pancreatic cancer has better clinical effect with fewer adverse reactions ,and it is worthy of popularization and application .
