CAJ | 학술논문

目的：探讨阴道镜联合高危型人乳头瘤病毒（ HR-HPV）检测对宫颈癌及宫颈上皮内瘤变的诊断价值。方法对644例行宫颈癌筛查的妇女行阴道镜和HR-HPV检测，并应用阴道镜取宫颈多点活组织进行病理检查。结果HR-HPV诊断结果阳性率为17．70％，阴道镜诊断结果阳性率为18．01％，HR-HPV＋阴道镜诊断结果阳性率为18．79％；HR-HPV＋阴道镜检测灵敏度和符合率与单一使用阴道镜或HR-HPV检测比较，P＜0．05，差异具有统计学意义；HR-HPV检测低危病变阳性率和高危病变阳性率比较，P＜0．05，差异具有统计学意义。结论阴道镜联合HR-HPV检测可提高宫颈癌及宫颈上皮内瘤变的诊断灵敏度和符合率，高危病变HR-HPV检测阳性率更高。
목적：탐토음도경연합고위형인유두류병독（ HR-HPV）검측대궁경암급궁경상피내류변적진단개치。방법대644례행궁경암사사적부녀행음도경화HR-HPV검측，병응용음도경취궁경다점활조직진행병리검사。결과HR-HPV진단결과양성솔위17．70％，음도경진단결과양성솔위18．01％，HR-HPV＋음도경진단결과양성솔위18．79％；HR-HPV＋음도경검측령민도화부합솔여단일사용음도경혹HR-HPV검측비교，P＜0．05，차이구유통계학의의；HR-HPV검측저위병변양성솔화고위병변양성솔비교，P＜0．05，차이구유통계학의의。결론음도경연합HR-HPV검측가제고궁경암급궁경상피내류변적진단령민도화부합솔，고위병변HR-HPV검측양성솔경고。
Objective To investigate the clinical application value of colposcopy and high -risk human papilloma virus ( HR-HPV) in the diagnosis of cervical cancer and cervical intraepithelial neoplasia .Methods 644 women who received colpos-copy and HR-HPV test for cervical cancer screening were taken more points of cervical tissues by colposcope for pathological ex -amination.Results HR-HPV diagnosis positive rate was 17.70%,the results of colposcopy diagnosis positive rate was 18.01%, HR-HPV+colposcopy diagnosis positive rate was 18.79%.Sensitivity and accuracy of HR-HPV+colposcopy detection compared with single use of colposcopy or HR-HPV detection,P<0.05,the difference was statistically significant;Comparison of HR-HPV positive detection rate of low-risk lesions and high-risk lesions,P<0.05,the difference was statistically significant .Conclusion Colposcopy combined with HR-HPV examination can improve the diagnostic sensitivity and accuracy of cervical cancer and cervi -cal intraepithelial neoplasia ,and high-risk lesions has higher HR-HPV positive rate.