CAJ | 학술논문

目的：检测喉癌及癌前病变组织中的HP（幽门螺杆菌）感染及环氧化酶-2（coX-2）表达，为寻找更有效的喉癌预防措施提供理论依据。方法免疫组化法和硼酸亚甲蓝法分别检测50例喉单纯增生、喉癌前病变、喉癌中HP感染情况和coX-2表达。结果喉单纯性增生、喉癌前病变、喉癌HP感染阳性率分别为：32%、66%、24%，P<0.05；coX-2表达阳性率分别为：18%、46%、80%，P<0.05；HP阳性组coX-2表达均高于HP阴性组，其中，HP阳性组喉癌前病变coX-2表达高于HP阴性组，P<0.05。结论1、HP感染可能是喉癌发生的一个早期事件；将为喉癌前期病变的干预性治疗提供一个临床的参考指标。2、coX-2的表达与喉癌的发生、发展可能有关。3、HP感染后诱导喉癌前病变中coX-2的表达，可能是HP致癌机制之一。
목적：검측후암급암전병변조직중적HP（유문라간균）감염급배양화매-2（coX-2）표체，위심조경유효적후암예방조시제공이론의거。방법면역조화법화붕산아갑람법분별검측50례후단순증생、후암전병변、후암중HP감염정황화coX-2표체。결과후단순성증생、후암전병변、후암HP감염양성솔분별위：32%、66%、24%，P<0.05；coX-2표체양성솔분별위：18%、46%、80%，P<0.05；HP양성조coX-2표체균고우HP음성조，기중，HP양성조후암전병변coX-2표체고우HP음성조，P<0.05。결론1、HP감염가능시후암발생적일개조기사건；장위후암전기병변적간예성치료제공일개림상적삼고지표。2、coX-2적표체여후암적발생、발전가능유관。3、HP감염후유도후암전병변중coX-2적표체，가능시HP치암궤제지일。
Objective By detecting the relationship between helicobacter pylori(HP) infection and the expression of cox-2 in laryngeal cancer and precancerous tissue,as to provide theoretical basis for looking for effective laryngeal cancer prevention measures. Methods the specimens from 50 cases of laryngeal simple hyperplastic , lesion before larynx cancer and laryngeal cancer ,were detected the diversity of positive expression rates of cox-2 by immunohistochemical method and detection of HP infection by improved borate methylene blue method. Result in throat simple hyperplastic,lesion before larynx cancer and laryngeal cancer:the positive rate of HP infection is respectively:32%,66%, 24%,P<0.05;the positive rate of cox-2 is respectively:18%,46%80%,P<0.05;Positive expression of cox-2 in HP positive group were higher than in HP negative group,among them,positive expression of cox-2 in HP positive group were higher than in HP negative group in the lesion before larynx cancer,P<0.05.Conclusion 1, HP infection may be an early event of laryngeal cancer and provide a clinical reference index with the interventional treatment of lesion before larynx cancer .2, the expression of cox-2 may be associated with the occurrence and development of laryngeal cancer. 3, after HP infection can induce the expression of cox-2 in the lesion before larynx cancer,may also is one of the HP carcinogenic mechanism.