CAJ | 학술논문

目的：探讨CXCR4、HPA、MMP-2在食管鳞癌组织中的表达和临床意义。方法应用免疫组化对120例手术切除的食管鳞癌标本和10例癌旁食管黏膜进行染色，检测CXCR4、HPA及MMP-2的表达，并探讨三者之间的相关性。结果 CXCR4、HPA和MMP-2在120例食管鳞癌组织中的阳性表达率分别为74．17％、58．33％、67．50％，明显高于癌旁组织（ P ＜0．05）。 CXCR4的表达与肿瘤的浸润深度、肿瘤大小、淋巴结转移、TNM分期有关（ P ＜0．05）；HPA的表达与肿瘤的浸润深度、肿瘤分化程度、TNM分期有关（ P ＜0．05）；MMP-2的表达与肿瘤的浸润深度、淋巴结转移、TNM分期有关（ P ＜0．05），CXCR4与HPA／MMP-2的表达具有显著相关性（ r ＝0．267， P ＝0．03／r ＝0．206， P＝0．024），HPA与MMP-2的表达无相关性（ r ＝0．153， P ＝0．093）。结论 CXCR4在食管鳞癌的发展过程中可能起主要作用，通过某些机制使HPA和／或MMP-2的活性增加，促进肿瘤的侵袭、转移。
목적：탐토CXCR4、HPA、MMP-2재식관린암조직중적표체화림상의의。방법응용면역조화대120례수술절제적식관린암표본화10례암방식관점막진행염색，검측CXCR4、HPA급MMP-2적표체，병탐토삼자지간적상관성。결과 CXCR4、HPA화MMP-2재120례식관린암조직중적양성표체솔분별위74．17％、58．33％、67．50％，명현고우암방조직（ P ＜0．05）。 CXCR4적표체여종류적침윤심도、종류대소、림파결전이、TNM분기유관（ P ＜0．05）；HPA적표체여종류적침윤심도、종류분화정도、TNM분기유관（ P ＜0．05）；MMP-2적표체여종류적침윤심도、림파결전이、TNM분기유관（ P ＜0．05），CXCR4여HPA／MMP-2적표체구유현저상관성（ r ＝0．267， P ＝0．03／r ＝0．206， P＝0．024），HPA여MMP-2적표체무상관성（ r ＝0．153， P ＝0．093）。결론 CXCR4재식관린암적발전과정중가능기주요작용，통과모사궤제사HPA화／혹MMP-2적활성증가，촉진종류적침습、전이。
Objective To investigate the expression and clinical significance of CXCR 4, HPA and MMP-2 in esophageal squamous cell cancer ( ESCC ) .Methods One hundred and twenty specimens of ESCC and 10 specimens of adjacent ESCC normal tissue were stained by immunohistochemisty ,then the expression levels of CXCR4,HPA,MMP-2 were detected,and the correlation among the three factors was analyzed .Results The positive expression rates of CXCR 4,HPA, MMP-2 in ESCC tissues were 74.17%,58.33%,67.50%,respectively,which were significantly higher than those in adjacent ESCC normal tissues ( P <0.05).The expression levels of CXCR4,HPA,MMP-2 were correlated to the infiltration depth , size,lymph node metastasis,TNM staging of ESCC ( P <0.05).The expression of CXCR4 was positively related with that of HPA/MMP-2 ( r =0.267/r =0.206, P <0.05),however,the expression of HPA was not correlated to that of MMP-2 ( P>0.05).Conclusion CXCR4 plays an important role during the progress of ESCC ,which may increase activity of HPA/MMP-2 through certain mechanisms ,as a result ,which may promote the invasion and metastasis of ESCC .