临床外科杂志
臨床外科雜誌
림상외과잡지
JOURNAL OF CLINICAL SURGERY
2014年
10期
746-748
,共3页
mGPS%胃癌%预后%预测
mGPS%胃癌%預後%預測
mGPS%위암%예후%예측
mGPS%gastric cancer%prognosis%predictor
目的:探讨术前改良Glasgow预后评分(modified Glasgow prognostic score,mGPS)对胃癌患者预后的预测价值。方法接受手术治疗的600例胃癌患者,按照mGPS评分标准将患者分为mGPS 2分组、mGPS 1分组、mGPS 0分组,比较组间患者术后生存情况,分析影响胃癌患者术后预后的相关危险因素。结果 mGPS1分46例(7.7%),mGPS2分33例(5.5%),mGPS0分521例(86.8%)。性别对患者术后总体生存情况的影响,组间差异无统计学意义(P=0.203),年龄、BMI、CEA、CA19-9、CRP、Alb、肿瘤TNM分期及mGPS 评分对总体生存情况的影响,组间差异有统计学意义(P<0.01)。性别、年龄、BMI、CEA、CA19-9及肿瘤分期等分组指标对mGPS评分的影响组间比较,差异有统计学意义(P<0.01)。术后死亡率影响因素的多因素分析结果显示,年龄(OR,1.319,95% CI 1.068,1.629,P<0.01),肿瘤分期(OR,2.909,95% CI 2.616,3.234,P<0.01),mGPS(OR,1.845,95% CI 1.184,2.875,P=0.007)与患者术后死亡率相关,是患者术后预后不良的危险因素。结论 mGPS评分可作为早期预测胃癌患者预后的简单、有效的临床指标。
目的:探討術前改良Glasgow預後評分(modified Glasgow prognostic score,mGPS)對胃癌患者預後的預測價值。方法接受手術治療的600例胃癌患者,按照mGPS評分標準將患者分為mGPS 2分組、mGPS 1分組、mGPS 0分組,比較組間患者術後生存情況,分析影響胃癌患者術後預後的相關危險因素。結果 mGPS1分46例(7.7%),mGPS2分33例(5.5%),mGPS0分521例(86.8%)。性彆對患者術後總體生存情況的影響,組間差異無統計學意義(P=0.203),年齡、BMI、CEA、CA19-9、CRP、Alb、腫瘤TNM分期及mGPS 評分對總體生存情況的影響,組間差異有統計學意義(P<0.01)。性彆、年齡、BMI、CEA、CA19-9及腫瘤分期等分組指標對mGPS評分的影響組間比較,差異有統計學意義(P<0.01)。術後死亡率影響因素的多因素分析結果顯示,年齡(OR,1.319,95% CI 1.068,1.629,P<0.01),腫瘤分期(OR,2.909,95% CI 2.616,3.234,P<0.01),mGPS(OR,1.845,95% CI 1.184,2.875,P=0.007)與患者術後死亡率相關,是患者術後預後不良的危險因素。結論 mGPS評分可作為早期預測胃癌患者預後的簡單、有效的臨床指標。
목적:탐토술전개량Glasgow예후평분(modified Glasgow prognostic score,mGPS)대위암환자예후적예측개치。방법접수수술치료적600례위암환자,안조mGPS평분표준장환자분위mGPS 2분조、mGPS 1분조、mGPS 0분조,비교조간환자술후생존정황,분석영향위암환자술후예후적상관위험인소。결과 mGPS1분46례(7.7%),mGPS2분33례(5.5%),mGPS0분521례(86.8%)。성별대환자술후총체생존정황적영향,조간차이무통계학의의(P=0.203),년령、BMI、CEA、CA19-9、CRP、Alb、종류TNM분기급mGPS 평분대총체생존정황적영향,조간차이유통계학의의(P<0.01)。성별、년령、BMI、CEA、CA19-9급종류분기등분조지표대mGPS평분적영향조간비교,차이유통계학의의(P<0.01)。술후사망솔영향인소적다인소분석결과현시,년령(OR,1.319,95% CI 1.068,1.629,P<0.01),종류분기(OR,2.909,95% CI 2.616,3.234,P<0.01),mGPS(OR,1.845,95% CI 1.184,2.875,P=0.007)여환자술후사망솔상관,시환자술후예후불량적위험인소。결론 mGPS평분가작위조기예측위암환자예후적간단、유효적림상지표。
Objective To investigate the prognostic value of modified Glasgow prognostic score(mGPS)in patients with gastric cancer.Methods The clinical data of 600 patients with gastric cancerwho underwent surgical treatment were retrospectively reviewed.These patients were divided into themGPS0 group,mGPS1 group,and mGPS2 group according to the standard of mGPS.Postoperative survivals and risk factors that may affect patient's prognosis were analyzed among the three groups.Results There were 46 (7.7%)cases,33 (5.5%)cases and 521 (86.8%)cases in the mGPS0,mGPS1 andmGPS2 group,respectively.Except for gender(P =0.203),age,BMI,CEA,CA199,CRP,Alb,TNM stageand mGPS affected the over all survivals and there were significant differences among the groups(P <0.01).Gender,age,BMI,CEA,CA199 and TNM stage affected the mGPS and there were significantdifferences among the groups(P <0.01).Multivariate analysis identified that age(OR,1.319,95% CI1.068,1.629,P <0.01),TNMstage(OR,2.909,95% CI 2.616,3.234,P <0.01)and mGPS(OR,1.845,95% CI 1.184,2.875,P =0.007)were correlated with the postoperative death rate and they wererisk factors of poor postoperative prognosis(P <0.01).Conclusion mGPS can be used as an early,simple and effective prognostic predictor of postoperative survival for patients with gastric cancer.