临床外科杂志
臨床外科雜誌
림상외과잡지
JOURNAL OF CLINICAL SURGERY
2014年
10期
738-741
,共4页
胃肠道间质瘤%临床特点%外科治疗
胃腸道間質瘤%臨床特點%外科治療
위장도간질류%림상특점%외과치료
gastrointestinal stromal tumor%clinical characteristics%surgical treatment
目的:总结胃肠道间质瘤(GIST)的病理及临床特点及其外科治疗和预后。方法回顾性分析我院术后病理证实的160例GIST患者的临床资料,其中随访145例,对其临床特点、病理特点、免疫标志物多因素进行预后的分析。结果160例行外科根治切除术患者,术中、术后均无死亡病例。生存的单因素分析病理特点显示,肿瘤的核分裂象、有无转移与Fletcher分级在胃肠间质瘤间差异有统计学意义(P<0.05);分析免疫组化 KIA、CD133免疫因子的阳性率分别为97.6%和81.3%。对生存预后有统计学意义(P<0.05)。术后随访145例(91.25%),其中53例多发肝转移患者,术后均进行甲磺酸伊马替尼(400 mg/d)药物治疗,疗效显著(P<0.05),多因素回归分析显示,Fletcher分级、甲磺酸伊马替尼是影响预后的独立危险因素。结论 Fletcher分级是评估GIST预后的有效手段,GIST患者采用外科根治性切除术联合甲磺酸伊马替尼治疗对原病灶、转移病灶治疗,其疗效显著。
目的:總結胃腸道間質瘤(GIST)的病理及臨床特點及其外科治療和預後。方法迴顧性分析我院術後病理證實的160例GIST患者的臨床資料,其中隨訪145例,對其臨床特點、病理特點、免疫標誌物多因素進行預後的分析。結果160例行外科根治切除術患者,術中、術後均無死亡病例。生存的單因素分析病理特點顯示,腫瘤的覈分裂象、有無轉移與Fletcher分級在胃腸間質瘤間差異有統計學意義(P<0.05);分析免疫組化 KIA、CD133免疫因子的暘性率分彆為97.6%和81.3%。對生存預後有統計學意義(P<0.05)。術後隨訪145例(91.25%),其中53例多髮肝轉移患者,術後均進行甲磺痠伊馬替尼(400 mg/d)藥物治療,療效顯著(P<0.05),多因素迴歸分析顯示,Fletcher分級、甲磺痠伊馬替尼是影響預後的獨立危險因素。結論 Fletcher分級是評估GIST預後的有效手段,GIST患者採用外科根治性切除術聯閤甲磺痠伊馬替尼治療對原病竈、轉移病竈治療,其療效顯著。
목적:총결위장도간질류(GIST)적병리급림상특점급기외과치료화예후。방법회고성분석아원술후병리증실적160례GIST환자적림상자료,기중수방145례,대기림상특점、병리특점、면역표지물다인소진행예후적분석。결과160례행외과근치절제술환자,술중、술후균무사망병례。생존적단인소분석병리특점현시,종류적핵분렬상、유무전이여Fletcher분급재위장간질류간차이유통계학의의(P<0.05);분석면역조화 KIA、CD133면역인자적양성솔분별위97.6%화81.3%。대생존예후유통계학의의(P<0.05)。술후수방145례(91.25%),기중53례다발간전이환자,술후균진행갑광산이마체니(400 mg/d)약물치료,료효현저(P<0.05),다인소회귀분석현시,Fletcher분급、갑광산이마체니시영향예후적독립위험인소。결론 Fletcher분급시평고GIST예후적유효수단,GIST환자채용외과근치성절제술연합갑광산이마체니치료대원병조、전이병조치료,기료효현저。
Objective To study the clinicalpathological characteristics,surgical treatment andprognosis of the gastrointestinal stromal tumor(GIST).Methods The clinical data of 160 cases of pathologically confirmed GIST were retrospectively reviewed.Clinical features,pathological characteristics andimmune markers were studied by multiple factor analysis.Results There were no intraoperative or deathsin 140 patients who underwent radical resection.Univariate analysis of survival revealed significant differences in the main tumor pathological characteristics,including mitotic figure and metastasis and Fletcher'sclassification(P <0.05).Immunohistochemical results showed that the positive rates of KIA and CD133were 97.6% and 81.3% respectively,and their influences to survival prognosis were of statistical significance(P <0.05).A total of 145(90.6%)patients finished the follow up and 53 cases of them had multiple liver metastasis.These patients received imatinib mesylate(400 mg/d)and the efficacy was significant(P <0.05).Multivariate regression analysis showed that Fletcher's classification and imatinib mesylatewere the independent risk factors affecting prognosis.Conclusion Fletcher's classification is an effectivemethod for evaluating the prognosis of GIST.Radical resection and imatinib mesylate can reach a remarkable curative effect in treating original and metastatic lesions of the GIST patients.