CAJ | 학술논문

目的计算并测定吡唑并[1,5-a]嘧啶酮类（PPOs）化合物QO-58，QO-58-L及QO-58-Cl的脂水分配系数，并比较两者的相符程度。方法摇瓶法（正辛醇/水）处理样品，水相用C18固相萃取小柱浓缩，高效液相色谱外标法测定QO-58，QO-58-L和QO-58-Cl水相和油相中的浓度，并分别计算其脂水分配系数（log P）。结果 QO-58的logP=2.43，QO-58-L的logP=1.07，QO-58-Cl的logP=5.50。结论 PPOs结构修饰后的脂水分配系数发生了较大改变，与计算结果趋势相符。
목적계산병측정필서병[1,5-a]밀정동류（PPOs）화합물QO-58，QO-58-L급QO-58-Cl적지수분배계수，병비교량자적상부정도。방법요병법（정신순/수）처리양품，수상용C18고상췌취소주농축，고효액상색보외표법측정QO-58，QO-58-L화QO-58-Cl수상화유상중적농도，병분별계산기지수분배계수（log P）。결과 QO-58적logP=2.43，QO-58-L적logP=1.07，QO-58-Cl적logP=5.50。결론 PPOs결구수식후적지수분배계수발생료교대개변，여계산결과추세상부。
Objective To calculate and detect the lipohilicity ( Log P ) of PPOs compound, including QO-58, QO-58-L, QO-58-Cl as M channel openers, and to compare the conformity of two results.Methods Determined by high performance liquid chromatography, the peak area of QO-58, QO-58-L and QO-58-Cl can infer their lipid-water partition coef icient ( octanol / water ). The fixed phase is Spherisorb C18 ( 34/118 ) 10L 4.6 í 250 mm reverse column, and the mobile phases are acetonitrile-0.2mol/L ammonium acetate ( 57:43, QO-58 ), acetonitrile-0.2mol/L ammonium acetate ( 57:43, QO-58-L ), methanol-0.2mol/L ammonium acetate ( 85:15, QO-58-Cl ). Results QO-58 log P=2.43, QO-58-L log P=1.07, QO-58-Cl log P=5.50.Conclusion After structural modification, the lipid-water partition coef icient of PPOs wil change. Software verifies its trend correct.