医学信息
醫學信息
의학신식
MEDICAL INFORMATION
2014年
15期
106-107
,共2页
奥美拉唑%治疗%溃疡性上消化道出血
奧美拉唑%治療%潰瘍性上消化道齣血
오미랍서%치료%궤양성상소화도출혈
Omeprazole%Treatment%Gastrointestinal hemorrhage of upper digestive ulcer
目的比较大剂量奥美拉唑和常规剂量奥美拉唑治疗溃疡性上消化道出血的治疗效果。方法选取156例患者随机分为治疗组和对照组各78例。治疗组院先给予奥美拉唑80mg加入生理盐水20ml缓慢静脉推注，约5~10min推完，然后再将奥美拉唑80mg加入生理盐水共50ml加入微量泵，以8mg/h的速度持续泵入,持续泵入72h；对照组院予奥美拉唑40mg加入生理盐水100ml，以q12h频率静脉滴注，用药72h。观察比较两组患者止血有效率、再出血情况、输红细胞悬液量、不良反应等。结果总有效率（<0.05）院治疗组94.8%，对照组总有效率为80.7%。72h再出血率（<0.05）院治疗组1.28%,对照组6.41%；平均每例输红细胞悬液输入量（<0.05）院治疗组(2.0±1.0)U,对照组(4.0±1.1)U；两组患者均无明显不良反应。结论大剂量奥美拉唑组对急性溃疡性上消化道出血止血效果明显优于常规剂量奥美拉唑组,无明显不良反应,且能缩短住院时间、节约患者住院费用，值得基层医院进一步推广应用。
目的比較大劑量奧美拉唑和常規劑量奧美拉唑治療潰瘍性上消化道齣血的治療效果。方法選取156例患者隨機分為治療組和對照組各78例。治療組院先給予奧美拉唑80mg加入生理鹽水20ml緩慢靜脈推註，約5~10min推完，然後再將奧美拉唑80mg加入生理鹽水共50ml加入微量泵，以8mg/h的速度持續泵入,持續泵入72h；對照組院予奧美拉唑40mg加入生理鹽水100ml，以q12h頻率靜脈滴註，用藥72h。觀察比較兩組患者止血有效率、再齣血情況、輸紅細胞懸液量、不良反應等。結果總有效率（<0.05）院治療組94.8%，對照組總有效率為80.7%。72h再齣血率（<0.05）院治療組1.28%,對照組6.41%；平均每例輸紅細胞懸液輸入量（<0.05）院治療組(2.0±1.0)U,對照組(4.0±1.1)U；兩組患者均無明顯不良反應。結論大劑量奧美拉唑組對急性潰瘍性上消化道齣血止血效果明顯優于常規劑量奧美拉唑組,無明顯不良反應,且能縮短住院時間、節約患者住院費用，值得基層醫院進一步推廣應用。
목적비교대제량오미랍서화상규제량오미랍서치료궤양성상소화도출혈적치료효과。방법선취156례환자수궤분위치료조화대조조각78례。치료조원선급여오미랍서80mg가입생리염수20ml완만정맥추주，약5~10min추완，연후재장오미랍서80mg가입생리염수공50ml가입미량빙，이8mg/h적속도지속빙입,지속빙입72h；대조조원여오미랍서40mg가입생리염수100ml，이q12h빈솔정맥적주，용약72h。관찰비교량조환자지혈유효솔、재출혈정황、수홍세포현액량、불량반응등。결과총유효솔（<0.05）원치료조94.8%，대조조총유효솔위80.7%。72h재출혈솔（<0.05）원치료조1.28%,대조조6.41%；평균매례수홍세포현액수입량（<0.05）원치료조(2.0±1.0)U,대조조(4.0±1.1)U；량조환자균무명현불량반응。결론대제량오미랍서조대급성궤양성상소화도출혈지혈효과명현우우상규제량오미랍서조,무명현불량반응,차능축단주원시간、절약환자주원비용，치득기층의원진일보추엄응용。
Objective To compare high-dose omeprazole and routine dose of omeprazole in the treatment of ulcerative upper digestive tract hemorrhage treatment ef ect. Methods 156 patients were randomly divided into treatment group and control group with 78 cases in each. Treatment group:first given omeprazole 80mg join saline 20ml slow intravenous injection, about 5~10 minutes to finish, and then omeprazole 80mg join saline 50ml adding trace pump continuous infusion, with the speed of 8mg/h, continuous infusion of 72 hours; the control group: Omeprazole 40mg join saline 100ml, at a frequency of q12h intravenous drug use, 72 hours. The two groups were observed and compared hemostatic efficiency, rebleeding rate, transmission and suspension of red blood cells, adverse reaction. Results The total ef ective rate ( <0.05):treatment group 94.8%, control group total ef ectiveness is 80.7%;. 72 re bleeding rate in H ( <0.05): treatment group 1.28%, control group 6.41%; the average cases of red blood celltransfusion suspension input ( <0.05): the treatment group (2 ± 1) U, the control group (4 ± 1.1) U; two groups were no obvious adverse reactions. Conclusion Large dose of omeprazole group on the hemostatic effect is bet er than conventional dose of omeprazole group of acute upper digestive tract bleeding ulcer, no significant adverse reactions, and can shorten the time of hospitalization, hospitalization cost saving, worthy of further application in basic hospital.
