CAJ | 학술논문

目的：观察阿司匹林治疗前列腺增生并急性尿潴留的临床疗效和安全性。方法选取沈阳市第一人民医院120例前列腺增生并急性尿潴留患者，随机分为阿司匹林组（60例）及对照组（60例）。阿司匹林组给予阿司匹林肠溶片联合非那雄胺、坦索罗欣治疗；对照组只给予非那雄胺和坦索罗欣治疗。随访6个月，观察和分析两组患者治疗前后前列腺大小、国际前列腺症状（IPSS）评分、最大尿流率、需手术治疗、急性尿潴留发生率及不良反应的情况。结果两组随访6个月后的前列腺大小、IPSS评分、最大尿流率与治疗前比较，差异均有统计学意义（均P＜0.05）。随访6个月后，两组的前列腺大小、IPSS评分、最大尿流率比较差异无统计学意义（P＞0.05）。阿司匹林组需手术治疗的患者比率及发生急性尿潴留率与对照组比较，差异统计学意义（x2=5.02、6.63，P＜0.05）。两组均未见不良反应发生。结论阿司匹林预防能有效治疗前列腺增生并急性尿潴留，降低了前列腺增生患者手术治疗风险，且并发症少。
목적：관찰아사필림치료전렬선증생병급성뇨저류적림상료효화안전성。방법선취침양시제일인민의원120례전렬선증생병급성뇨저류환자，수궤분위아사필림조（60례）급대조조（60례）。아사필림조급여아사필림장용편연합비나웅알、탄색라흔치료；대조조지급여비나웅알화탄색라흔치료。수방6개월，관찰화분석량조환자치료전후전렬선대소、국제전렬선증상（IPSS）평분、최대뇨류솔、수수술치료、급성뇨저류발생솔급불량반응적정황。결과량조수방6개월후적전렬선대소、IPSS평분、최대뇨류솔여치료전비교，차이균유통계학의의（균P＜0.05）。수방6개월후，량조적전렬선대소、IPSS평분、최대뇨류솔비교차이무통계학의의（P＞0.05）。아사필림조수수술치료적환자비솔급발생급성뇨저류솔여대조조비교，차이통계학의의（x2=5.02、6.63，P＜0.05）。량조균미견불량반응발생。결론아사필림예방능유효치료전렬선증생병급성뇨저류，강저료전렬선증생환자수술치료풍험，차병발증소。
Objective To observe the clinical effect and safety on aspirin in the treatment of benign prostatic hyperplasla (BPH) combined with acute urine retention (AUR). Methods 120 BPH patients with AUR of our hospital were selected and divided into aspirin treatment (60 cases) and control groups (60 cases).Aspirin group was given finasteride, tamsulosin and aspirin, control group was given finasteride and tamsulosin.Volume of prostate.Follow up with 6 mouths, size of the prostate, IPSS scores, maximum urine flow rate, need surgery cases, cases of AUR and severe side effect related aspirin of two groups before and after treatment were observed. Results There were significant differences on the size of the prostate, IPSS scores, maximum urine flow rate of two groups after followed up for 6 months compared with before treatment (P<0.05). There were no significant differences on the size of the prostate, IPSS scores, maximum urine flow rate of aspirin group after followed up for 6 months compared with that of control group (P>0.05). There were significant differences on the rate of need surgery and AUR rate of aspirin group compared with control group (x2=5.02, 6.63, P<0.05). There was no side effect in two groups. Conclusion Aspirin have a good effect in the treatment of BPH combined with AUR, and reduce the surgery risk of BPH patients with less adverse reaction.