CAJ | 학술논문

目的：研究分析三氧治疗联合调强适形放疗治疗鼻咽癌的疗效及对患者血清乏氧诱导因子-1α（HIF-1α）及血管内皮生长因子（VEGF）的影响。方法选取我院2010年1月～2013年12月收治的鼻咽癌放疗患者50例进行治疗观察，随机分为两组，每组各25例。对照组行调强放疗，观察组在对照组治疗基础上行三氧联合治疗。结果治疗后，观察组鼻咽癌患者血清HIF-1α水平显著下降，对照组则显著升高，差异均有统计学意义（P＜0.01～0.05）。治疗后，观察组鼻咽癌患者血清HIF-1α水平显著低于对照组，差异有统计学意义（P＜0.01）。治疗后，观察组鼻咽癌患者血清VEGF水平显著下降，对照组则显著升高，差异均有统计学意义（P＜0.01）。治疗后，观察组鼻咽癌患者血清VEGF水平显著低于对照组，差异有统计学意义（P＜0.01）。结论三氧治疗联合调强适形放疗治疗鼻咽癌的疗效显著，能改善患者的血清乏氧诱导因子-1α及血管内皮生长因子水平。
목적：연구분석삼양치료연합조강괄형방료치료비인암적료효급대환자혈청핍양유도인자-1α（HIF-1α）급혈관내피생장인자（VEGF）적영향。방법선취아원2010년1월～2013년12월수치적비인암방료환자50례진행치료관찰，수궤분위량조，매조각25례。대조조행조강방료，관찰조재대조조치료기출상행삼양연합치료。결과치료후，관찰조비인암환자혈청HIF-1α수평현저하강，대조조칙현저승고，차이균유통계학의의（P＜0.01～0.05）。치료후，관찰조비인암환자혈청HIF-1α수평현저저우대조조，차이유통계학의의（P＜0.01）。치료후，관찰조비인암환자혈청VEGF수평현저하강，대조조칙현저승고，차이균유통계학의의（P＜0.01）。치료후，관찰조비인암환자혈청VEGF수평현저저우대조조，차이유통계학의의（P＜0.01）。결론삼양치료연합조강괄형방료치료비인암적료효현저，능개선환자적혈청핍양유도인자-1α급혈관내피생장인자수평。
Objective To study and analyze the efficacy of three-oxygen therapy combined with intensity modulated radiation therapy in the treatment of nasopharyngeal cancer and its influence on the patients' serum hypoxia inducible factor-1(HIF-1α) and vascular endothelial growth factors(VEGF). Methods Fifty patients with nasopharyngeal cancer treated in our hospital from January 2010 to December 2013 were selected to receive treatment and randomly divided into two groups.The control group received intensity modulated radiation therapy and the observation group received three-oxygen therapy on the basis of the control group. Results After treatment, the serum HIF-1α level of the observation group reduced significantly and that of the control group elevated significantly,with statistically significant differences for both(P < 0.01-0.05).After treatment, the serum HIF-1α level of the observation group was significantly lower than that of the control group, with statistically significant difference(P < 0.01). After treatment, the serum VEGF level of the observation group reduced significantly and that of the control group elevated significantly, with statistically significant differences for both(P < 0.01). After treatment, the serum VEGF level of the observation group was significantly lower than that of the control group, with statistically significant difference(P<0.01). Conclusion Three-oxygen therapy combined with intensity modulated radiation therapy shows remarkable efficacy in the treatment of nasopharyngeal cancer and can improve the patients' serum levels of hypoxia inducible factor-1αand vascular endothelial growth factors.