中国实用眼科杂志
中國實用眼科雜誌
중국실용안과잡지
CHINESE JOURNAL OF PRACTICAL OPHTHALMOLOGY
2013年
2期
150-153
,共4页
于洋洋%甄毅%王文欣%张舒心
于洋洋%甄毅%王文訢%張舒心
우양양%견의%왕문흔%장서심
开角型青光眼%拉坦前列腺素%24 h眼压
開角型青光眼%拉坦前列腺素%24 h眼壓
개각형청광안%랍탄전렬선소%24 h안압
Open-angle glaucoma%Latanoprost%24-hour intraocular pressure
目的 通过观察原发性开角型青光眼(POAG)患者使用拉坦前列腺素前后24h眼压曲线的变化,评价其24 h降眼压效果,为临床应用提供指导.方法 回顾性分析2010年1月至2010年7月在首都医科大学附属北京同仁医院眼科中心接受24 h眼压监测患者的病历,筛选出使用拉坦前列腺素进行初次治疗的POAG患者.比较在用药前后24 h眼压曲线的变化.眼压测量使用回弹式眼压计,测量时间点为10:00、14:00、18:00、22:00、2:00、6:00和8:00.结果 共有26例入选,其中男性12例,女性14例,平均年龄(49±15)岁.用药后不同时间点眼压降低的幅度在4.0～6.3 mmHg,除2:00外,其余时间点用药前后的差别有统计学意义.用药前眼压的峰值、均值、24h波动值分别为(26.3±7.7)、(21.9±6.3)和(8.4±3.2) mm Hg,用药后相应值分别为(21.7±5.6)、(16.9±4.0)和(8.4±4.1) mm Hg,较用药前分别降低(4.6±3.8)mm Hg (F =6.14,P=0.017)、(5.0±2.9) (F=11.33,P=0.001)和(0.1±4.3) mm Hg (F =0.004,P=0.951).结论 除2:00点外,拉坦前列腺素在其他时间点均可明显降低眼压,24h眼压的峰值和均值亦有明显降低,但对眼压波动无明显影响.
目的 通過觀察原髮性開角型青光眼(POAG)患者使用拉坦前列腺素前後24h眼壓麯線的變化,評價其24 h降眼壓效果,為臨床應用提供指導.方法 迴顧性分析2010年1月至2010年7月在首都醫科大學附屬北京同仁醫院眼科中心接受24 h眼壓鑑測患者的病歷,篩選齣使用拉坦前列腺素進行初次治療的POAG患者.比較在用藥前後24 h眼壓麯線的變化.眼壓測量使用迴彈式眼壓計,測量時間點為10:00、14:00、18:00、22:00、2:00、6:00和8:00.結果 共有26例入選,其中男性12例,女性14例,平均年齡(49±15)歲.用藥後不同時間點眼壓降低的幅度在4.0～6.3 mmHg,除2:00外,其餘時間點用藥前後的差彆有統計學意義.用藥前眼壓的峰值、均值、24h波動值分彆為(26.3±7.7)、(21.9±6.3)和(8.4±3.2) mm Hg,用藥後相應值分彆為(21.7±5.6)、(16.9±4.0)和(8.4±4.1) mm Hg,較用藥前分彆降低(4.6±3.8)mm Hg (F =6.14,P=0.017)、(5.0±2.9) (F=11.33,P=0.001)和(0.1±4.3) mm Hg (F =0.004,P=0.951).結論 除2:00點外,拉坦前列腺素在其他時間點均可明顯降低眼壓,24h眼壓的峰值和均值亦有明顯降低,但對眼壓波動無明顯影響.
목적 통과관찰원발성개각형청광안(POAG)환자사용랍탄전렬선소전후24h안압곡선적변화,평개기24 h강안압효과,위림상응용제공지도.방법 회고성분석2010년1월지2010년7월재수도의과대학부속북경동인의원안과중심접수24 h안압감측환자적병력,사선출사용랍탄전렬선소진행초차치료적POAG환자.비교재용약전후24 h안압곡선적변화.안압측량사용회탄식안압계,측량시간점위10:00、14:00、18:00、22:00、2:00、6:00화8:00.결과 공유26례입선,기중남성12례,녀성14례,평균년령(49±15)세.용약후불동시간점안압강저적폭도재4.0～6.3 mmHg,제2:00외,기여시간점용약전후적차별유통계학의의.용약전안압적봉치、균치、24h파동치분별위(26.3±7.7)、(21.9±6.3)화(8.4±3.2) mm Hg,용약후상응치분별위(21.7±5.6)、(16.9±4.0)화(8.4±4.1) mm Hg,교용약전분별강저(4.6±3.8)mm Hg (F =6.14,P=0.017)、(5.0±2.9) (F=11.33,P=0.001)화(0.1±4.3) mm Hg (F =0.004,P=0.951).결론 제2:00점외,랍탄전렬선소재기타시간점균가명현강저안압,24h안압적봉치화균치역유명현강저,단대안압파동무명현영향.
Objective To evaluate the effect of latanoprost reducing Me 24-hour intraocular pressure (IOP) and supply directions for clinical application,observing the change of 24-hour IOP in primary open-angle glaucoma (POAG) patients.Methods Retrospective analyzed the patients' case files who received the monitoring of 24-hour IOP in Beijing Tongren Eye Center,Beijing Tongren Hospital,Capital Medical University from January to July,2010.And those POAG patients who first received latanoprost therapy were selected.The differences of 24-hour IOP curve before and after medication were compared.Icare rebounder tonomer was used,the IOP were measured at 10 am,2pm,6pm,10pm,2am,6am and 8am.Results The amplitude of lowering IOP after medication was 4.0-6.3mmHg in different time except for 2 am,there was a statistically significant difference before and after medication in other time.The peak,mean and 24-hour IOP were 26.3±7.7,21.9±6.3,8.4±3.2mmHg before medication,and 21.7±5.6,16.9±4.0,8.4±4.1mmHg after medication respectively.Separately reducing the IOP 4.6±3.8 (F =6.14,P =0.017),5.0±2.9 (F =11.33,P =0.001) and 0.1±4.3mmHg (F =0.004,P =0.951).Conclusions Latanprost provide effective 24-hour lOP reduction except for 2 am.The peak and mean IOP are significantly reduced in 24-hour IOP.However,latanoprost has no significantly effect for fluctuation of IOP.
