CAJ | 학술논문

铁过度累积可加重胰岛素抵抗,对2型糖尿病的发生、发展具有推动作用.铁代谢调节机制中涉及铁调素,它是铁代谢的核心调节剂,能抑制铁的吸收和释放.有研究发现,2型糖尿病患者血清铁调素水平较正常人升高,但关于铁调素参与2型糖尿病的机制目前研究甚少.通过对铁调素与2型糖尿病关系的研究发现,在2型糖尿病患者中铁调素与铁蛋白呈正相关.铁调素与糖代谢有关,其可能通过对铁代谢的调节在2型糖尿病中发挥一定作用,从而为2型糖尿病的防治提供新思路.
철과도루적가가중이도소저항,대2형당뇨병적발생、발전구유추동작용.철대사조절궤제중섭급철조소,타시철대사적핵심조절제,능억제철적흡수화석방.유연구발현,2형당뇨병환자혈청철조소수평교정상인승고,단관우철조소삼여2형당뇨병적궤제목전연구심소.통과대철조소여2형당뇨병관계적연구발현,재2형당뇨병환자중철조소여철단백정정상관.철조소여당대사유관,기가능통과대철대사적조절재2형당뇨병중발휘일정작용,종이위2형당뇨병적방치제공신사로.
Excessive accumulation of iron can aggravate insulin resistance,promote the development of type 2 diabetes.Hepcidin is related to iron metabolism regulation,which is a core regulator of iron metabolism and can inhibit the absorption and release of iron.Studies have found serum hepcidin levels were higher in type 2 diabetic patients than those in normal people,but the mechanisms of hepcidin involved in type 2 diabetes are few.It was found that hepcidin was positively correlated with ferritin in type 2 diabetic patientsthrough studies about the relationship between hepcidin and type 2 diabetes.Hepcidin is related with glucose metabolism,and plays a role in type 2 diabetes through regulating iron metabolism,thereby provides new ideas for the prevention and treatment of type 2 diabetes.