CAJ | 학술논문

　　目的探讨接受左旋多巴治疗的帕金森病（PD）患者血同型半胱氨酸水平与临床特征的关系及测定的意义。方法测定44例PD患者（PD组）与38例健康体检者（对照组）的血同型半胱氨酸、叶酸、维生素B12水平并进行比较，将PD组分为≥14mmol/L与＜14mmol/L两个亚组，比较两组统一帕金森量表评分。分析PD患者血同型半胱氨酸水平的影响因素。结果 PD组患者血同型半胱氨酸水平[（16.1±7.8）μmol/L]高于对照组[（10.9±2.8）μmol/L]，高同型半胱氨酸水平与叶酸、维生素B12水平呈负相关（r=-0.467，P＜0.01；r=-0.347，P＜0.05），与左旋多巴用量及UPDRSⅢ呈正相关（r=0.464，P＜0.01；r=0.378，P＜0.05），与年龄、起病年龄、病程、左旋多巴使用时间无关（均P＞0.05），≥14mmol/L与＜14mmol/L两组UPDRS评分的差异无统计学意义（P＞0.05）。结论左旋多巴治疗会导致高同型半胱氨酸血症发生，补充叶酸及维生素B12治疗可能是有效的治疗方法。
　　목적탐토접수좌선다파치료적파금삼병（PD）환자혈동형반광안산수평여림상특정적관계급측정적의의。방법측정44례PD환자（PD조）여38례건강체검자（대조조）적혈동형반광안산、협산、유생소B12수평병진행비교，장PD조분위≥14mmol/L여＜14mmol/L량개아조，비교량조통일파금삼량표평분。분석PD환자혈동형반광안산수평적영향인소。결과 PD조환자혈동형반광안산수평[（16.1±7.8）μmol/L]고우대조조[（10.9±2.8）μmol/L]，고동형반광안산수평여협산、유생소B12수평정부상관（r=-0.467，P＜0.01；r=-0.347，P＜0.05），여좌선다파용량급UPDRSⅢ정정상관（r=0.464，P＜0.01；r=0.378，P＜0.05），여년령、기병년령、병정、좌선다파사용시간무관（균P＞0.05），≥14mmol/L여＜14mmol/L량조UPDRS평분적차이무통계학의의（P＞0.05）。결론좌선다파치료회도치고동형반광안산혈증발생，보충협산급유생소B12치료가능시유효적치료방법。
Objective To investigate the association of levodopa administration with hyperhomocysteinemia in patients with Parkinson's disease (PD). Methods Forty four PD patients and 38 healthy subjects were included in the study. The serum homocysteine, folic acid and vitamin B12 levels were measured. Pearson correlation was applied to analyze related factors influ-encing blood homocysteine levels. The scores of unified Parkinson's disease rating scale III (UPDRSIII) were compared between patients with homocysteine level>14 mmol/l and those<14 mmol/l. Results Homocysteine levels were significantly higher in PD patients than those in controls. Hyperhomocysteinemia was negatively correlated with vitamin B12 and folate levels and positively correlated with UPDRS scores and levodopa dose. There was no correlation of homocysteine level with age, onset age and dura-tion of disease, duration of levodopa administration. There were no significant difference in UPDRS scores between >14mmol/l and<14mmol/l subgroups. Conclusion Administration of levodopa is associated with UPDRS and high blood homocysteine lev-els,which indicates that levodopa may induce hyperhomocysteinemia in patients with Parkinson's disease.