现代肿瘤医学
現代腫瘤醫學
현대종류의학
JOURNAL OF MODERN ONCOLOGY
2014年
5期
1191-1195
,共5页
DAL-1%胃癌%基因表达%甲基化
DAL-1%胃癌%基因錶達%甲基化
DAL-1%위암%기인표체%갑기화
DAL - 1%gastric cancer%gene exPression%methylation
人类 DAL -1基因编码4.1B 蛋白，是膜/细胞骨架相关蛋白4.1超家族成员之一，参与维持细胞正常形态和生理功能。在人类大多数肿瘤中 DAL -1基因表达下调，研究表明其功能失活与该基因启动子区 CPG 岛甲基化密切相关。本综述将侧重 DAL -1基因在肿瘤发生发展中的研究进展。
人類 DAL -1基因編碼4.1B 蛋白，是膜/細胞骨架相關蛋白4.1超傢族成員之一，參與維持細胞正常形態和生理功能。在人類大多數腫瘤中 DAL -1基因錶達下調，研究錶明其功能失活與該基因啟動子區 CPG 島甲基化密切相關。本綜述將側重 DAL -1基因在腫瘤髮生髮展中的研究進展。
인류 DAL -1기인편마4.1B 단백，시막/세포골가상관단백4.1초가족성원지일，삼여유지세포정상형태화생리공능。재인류대다수종류중 DAL -1기인표체하조，연구표명기공능실활여해기인계동자구 CPG 도갑기화밀절상관。본종술장측중 DAL -1기인재종류발생발전중적연구진전。
euman gene DAL - 1 encodes 4. 1B Protein is a member of membrane/ cytoskeleton - associated Protein 4. 1 suPerfamily. It is involved in maintaining normal cell morPhology and Physiological functions. The exPression of DAL - 1 gene is frequently downregulated in a variety of different human cancers,and its functional inactivation is closely related to the methylation of Promoter CPG island. This review focused on the role of DAL - 1 gene in develoP-ment of tumor.
