CAJ | 학술논문

　　目的：探讨林可霉素治疗肺炎发生的药品不良反应(ADR)的规律和特点。方法：回顾性分析2006年2月-2013年1月笔者所在医院静脉滴注林可霉素治疗肺炎出现不良反应的168例患者的临床资料。结果：林可霉素所致ADR可累及全身各个系统，其中胃肠道系统损害107例(63.7%)和皮疹20例(11.9%)；过敏性休克2例(1.2%)、循环系统损害10例(6.0%)、神经系统2例(1.2%)、下肢水肿8例(5.0%)、肝功能损害6例(3.6%)、泌尿系统损害13例(7.7%)；男94例(56.0%)，女74例(44.0%)，ADR可发生于用药后的各个时间段。结论：应重视林可霉素所致过ADR，加强监测，以减少不良反应的发生。
　　목적：탐토림가매소치료폐염발생적약품불량반응(ADR)적규률화특점。방법：회고성분석2006년2월-2013년1월필자소재의원정맥적주림가매소치료폐염출현불량반응적168례환자적림상자료。결과：림가매소소치ADR가루급전신각개계통，기중위장도계통손해107례(63.7%)화피진20례(11.9%)；과민성휴극2례(1.2%)、순배계통손해10례(6.0%)、신경계통2례(1.2%)、하지수종8례(5.0%)、간공능손해6례(3.6%)、비뇨계통손해13례(7.7%)；남94례(56.0%)，녀74례(44.0%)，ADR가발생우용약후적각개시간단。결론：응중시림가매소소치과ADR，가강감측，이감소불량반응적발생。
Objective:To explore the rules and characteristics of adverse drug reaction (ADR) of lincomycin in treatment with Pneumonia.Methods:Retrospective analysis of 2006 February-2013 year in January in my hospital intravenous infusion of forests in the clinical data of 168 cases of pneumonia of kanamycintreatment adverse reactions.Results:Clindamycin ADR may be caused by involving the whole body each system,including the gastrointestinal system damage in 107 cases (63.7%) and rash 20 cases (11.9%);Anaphylactic shock in 2 cases (1.2%),circulatory system,10 cases (6.0%),nervous system damage in 2 cases (1.2%),lower extremity edema,8 cases (5.0%),6 cases of liver damage (3.6%),urinary tract damage in 13 (7.7%);94 cases (56.0%),male,74 female patients (44.0%),can happen after the drug (ADR) of each time period.Conclusion:Should pay attention to ADR caused by clindamycin,strengthen monitoring,in order to reduce the occurrence of adverse reactions.