CAJ | 학술논문

　　目的：探讨慢性心功能不全患者血清脂肪因子Chemerin的变化及其临床意义。方法：52例慢性左心功能不全(射血分数EF<45%)患者，以年龄、性别和有无糖尿病史1∶1匹配选取心功能正常患者作为非心衰对照组，26例健康人群为正常对照组，检测体质指数、NT-proBNP等临床及生化指标，ELISA方法检测血浆Chemerin和肿瘤坏死因子α(TNF-α)水平，进行对比研究。结果：心衰患者血浆Chemerin水平较非心衰患者(P<0.001)及正常对照组(P<0.001)明显升高，且随心衰加重而明显升高，多元回归分析显示甘油三酯(r=0.270，P=0.021)、HOMA-IR(r=0.319，P=0.005)、体质指数(r=0.250，P=0.029)、肿瘤坏死因子-α(r=0.348，P=0.003)是影响Chemerin水平的相关因素。结论：Chemerin不仅参与肥胖和代谢综合征的内分泌调节，亦通过参与免疫炎症反应，在心力衰竭的发生发展中发挥重要作用。
　　목적：탐토만성심공능불전환자혈청지방인자Chemerin적변화급기림상의의。방법：52례만성좌심공능불전(사혈분수EF<45%)환자，이년령、성별화유무당뇨병사1∶1필배선취심공능정상환자작위비심쇠대조조，26례건강인군위정상대조조，검측체질지수、NT-proBNP등림상급생화지표，ELISA방법검측혈장Chemerin화종류배사인자α(TNF-α)수평，진행대비연구。결과：심쇠환자혈장Chemerin수평교비심쇠환자(P<0.001)급정상대조조(P<0.001)명현승고，차수심쇠가중이명현승고，다원회귀분석현시감유삼지(r=0.270，P=0.021)、HOMA-IR(r=0.319，P=0.005)、체질지수(r=0.250，P=0.029)、종류배사인자-α(r=0.348，P=0.003)시영향Chemerin수평적상관인소。결론：Chemerin불부삼여비반화대사종합정적내분비조절，역통과삼여면역염증반응，재심력쇠갈적발생발전중발휘중요작용。
Objective:To compare plasma Chemerin levels in patients with chronic heart failure(CHF) and in control subjects,and assesse the association of plasma Chemerin with body composition and metabolic parameters in these subjects.Methods:Serum Chemerin and Tumor Necrosis Factor-α(TNF-α) levels were measured by ELISA in 52 patients with CHF and in 52 age,tender,diabetes-history matched controls with cardiovascular disease but normal heart function, and in 26 healthy volunteers.Furthermore,the association between chemerin and NT-proBNP,TNF-α as well as metabolism markers were studied. Results:Plasma Chemerin levels were found to be markedly increased in patients with CHF as compared with patients without CHF and normal controls(P<0.001). Multiple regression analysis showed that TG(r=0.270,P=0.021),body mass index(r=0.250,P=0.029),HOMA-IR(r=0.319,P=0.005) and TNF-α(r=0.348, P=0.003) were independently related factors influencing plasma Chemerin levels.Conclusion:The present work indicates the potential role of Chemerin in the pathogenesis of chronic heart failure through the immune response.