CAJ | 학술논문

　　目的研究水药骂广瓦的镇痛抗炎作用。方法通过醋酸诱发小鼠扭体及热板法致痛、二甲苯所致耳廓肿胀实验，比较分析生理盐水组（空白对照组）、阿司匹林组（阳性对照组）、骂广瓦0．84 g/kg组（Ⅰ组）、0．42 g/kg组（Ⅱ组）、0．21 g/kg组（Ⅲ组）的镇痛抗炎效果。结果阳性对照组、Ⅰ组、Ⅱ组的扭体潜伏期均较空白对照组明显延长（P＜0．05），与空白对照组比较，阳性对照组、Ⅰ组、Ⅱ组的扭体次数也均明显减少（P＜0．05），Ⅲ组的扭体潜伏期、扭体次数与空白对照组比较差异无统计学意义（P＞0．05）；用药前各组小鼠的痛阈值比较差异均无统计学意义（P＞0．05），用药后30、60、90、120 min ，阳性对照组、Ⅰ组、Ⅱ组的痛阈值均较空白对照组明显升高（P＜0．05），同时，Ⅰ组的痛阈值与阳性对照组比较差异无统计学意义（P＞0．05），Ⅲ组的痛阈值与空白对照组比较差异无统计学意义（P＞0．05）；与空白对照组比较，阳性对照组、Ⅰ组、Ⅱ组的右耳质量显著降低（P＜0．05），并且阳性对照组、Ⅰ组、Ⅱ组的肿胀度也显著降低（P＜0．05），而Ⅰ组的右耳质量和肿胀度与阳性对照组比较差异均无统计学意义（P＞0．05），Ⅲ组的右耳质量及肿胀度与空白对照组比较差异无统计学意义（P＞0．05）。结论水药骂广瓦具有较强的镇痛抗炎作用，且作用呈一定的量效关系。
　　목적연구수약매엄와적진통항염작용。방법통과작산유발소서뉴체급열판법치통、이갑분소치이곽종창실험，비교분석생리염수조（공백대조조）、아사필림조（양성대조조）、매엄와0．84 g/kg조（Ⅰ조）、0．42 g/kg조（Ⅱ조）、0．21 g/kg조（Ⅲ조）적진통항염효과。결과양성대조조、Ⅰ조、Ⅱ조적뉴체잠복기균교공백대조조명현연장（P＜0．05），여공백대조조비교，양성대조조、Ⅰ조、Ⅱ조적뉴체차수야균명현감소（P＜0．05），Ⅲ조적뉴체잠복기、뉴체차수여공백대조조비교차이무통계학의의（P＞0．05）；용약전각조소서적통역치비교차이균무통계학의의（P＞0．05），용약후30、60、90、120 min ，양성대조조、Ⅰ조、Ⅱ조적통역치균교공백대조조명현승고（P＜0．05），동시，Ⅰ조적통역치여양성대조조비교차이무통계학의의（P＞0．05），Ⅲ조적통역치여공백대조조비교차이무통계학의의（P＞0．05）；여공백대조조비교，양성대조조、Ⅰ조、Ⅱ조적우이질량현저강저（P＜0．05），병차양성대조조、Ⅰ조、Ⅱ조적종창도야현저강저（P＜0．05），이Ⅰ조적우이질량화종창도여양성대조조비교차이균무통계학의의（P＞0．05），Ⅲ조적우이질량급종창도여공백대조조비교차이무통계학의의（P＞0．05）。결론수약매엄와구유교강적진통항염작용，차작용정일정적량효관계。
Objective To investigate the analgesic and anti-inflammatory effects of Shui ethnic medicine Maguangwa .Methods Acetic acid-provoked writhing and hot plate provocation of pain were adopted to observe the analgesic effect of Shui ethnic medicine Maguangwa ,and xylene-induced ear swelling was used to observe the anti-inflammatory effect of Shui ethnic medicine Maguangwa There were five experimental groups ,i .e .,the blank control group ,the aspirin group(positive control) ,the 0 .84 g/kg Shui ethnic medicine Maguangwa group(group Ⅰ) ,the 0 .42 g/kg Shui ethnic medicine Maguangwa group(group Ⅱ ) ,and the 0 .21 g/kg Shui ethnic medicine Maguangwa group(group Ⅲ) .Results The writhing latency increased significantly and the writhing frequency de-creased significantly in the positive control group ,group Ⅰ and group Ⅱ ,when compared with the blank control group(P<0 .05) . The writhing latency and frequency differed insignificantly between group Ⅲ and the blank control group(P>0 .05) .Before medica-tion the pain threshold of mice in each group differed insignificantly (P>0 .05) .At 30 min ,60 min ,90 min and 120 min after medi-cation ,the pain threshold increased significantly in the positive control group ,group Ⅰ ,and group Ⅱ ,when compared to the blank control group(P<0 .05) .Meanwhile ,the pain threshold differed insignificantly between group Ⅰ and the positive control group(P>0 .05) ,or between group Ⅲ and the blank control group(P>0 .05) .When compared with the blank control group ,the right ear mass and degree of swelling decreased significantly in the positive control group ,group I and group Ⅱ (P<0 .05) .However ,the right ear mass and degree of swelling differed insignificantly between group Ⅰ and the positive control group(P>0 .05) ,or between group Ⅲ and the blank control group(P>0 .05) .Conclusion Shui ethnic medicine Maguangwa exhibits potent analgesic and anti-inflammatory effects in a dose-dependent manner .